Gao Keming, Wu Renrong, Wang Zuowei, Ren Ming, Kemp David E, Chan Philip K, Conroy Carla M, Serrano Mary Beth, Ganocy Stephen J, Calabrese Joseph R
Mood and Anxiety Clinic in the Mood Disorders Program of the Department of Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, USA.
Mood and Anxiety Clinic in the Mood Disorders Program of the Department of Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, USA.
J Psychiatr Res. 2015 Jan;60:117-24. doi: 10.1016/j.jpsychires.2014.09.011. Epub 2014 Sep 19.
To study the disagreement between self-reported suicidal ideation (SR-SI) and clinician-ascertained suicidal ideation (CA-SI) and its correlation with depression and anxiety severity in patients with major depressive disorder (MDD) or bipolar disorder (BPD).
Routine clinical outpatients were diagnosed with the MINI-STEP-BD version. SR-SI was extracted from the 16 Item Quick Inventory of Depression Symptomatology Self-Report (QIDS-SR-16) item 12. CA-SI was extracted from a modified Suicide Assessment module of the MINI. Depression and anxiety severity were measured with the QIDS-SR-16 and Zung Self-Rating Anxiety Scale. Chi-square, Fisher exact, and bivariate linear logistic regression were used for analyses.
Of 103 patients with MDD, 5.8% endorsed any CA-SI and 22.4% endorsed any SR-SI. Of the 147 patients with BPD, 18.4% endorsed any CA-SI and 35.9% endorsed any SR-SI. The agreement between any SR-SI and any CA-SI was 83.5% for MDD and 83.1% for BPD, with weighted Kappa of 0.30 and 0.43, respectively. QIDS-SR-16 score, female gender, and ≥4 year college education were associated with increased risk for disagreement, 15.44 ± 4.52 versus 18.39 ± 3.49 points (p = 0.0026), 67% versus 46% (p = 0.0783), and 61% versus 29% (p = 0.0096). The disagreement was positively correlated to depression severity in both MDD and BPD with a correlation coefficient R(2) = 0.40 and 0.79, respectively, but was only positively correlated to anxiety severity in BPD with a R(2) = 0.46.
Self-reported questionnaire was more likely to reveal higher frequency and severity of SI than clinician-ascertained, suggesting that a combination of self-reported and clinical-ascertained suicidal risk assessment with measuring depression and anxiety severity may be necessary for suicide prevention.
研究重度抑郁症(MDD)或双相情感障碍(BPD)患者自我报告的自杀意念(SR-SI)与临床医生确定的自杀意念(CA-SI)之间的差异及其与抑郁和焦虑严重程度的相关性。
对常规临床门诊患者采用MINI-STEP-BD版本进行诊断。SR-SI从16项抑郁症状快速自评量表(QIDS-SR-16)的第12项中提取。CA-SI从MINI的改良自杀评估模块中提取。抑郁和焦虑严重程度分别用QIDS-SR-16和zung自评焦虑量表进行测量。采用卡方检验、Fisher精确检验和双变量线性逻辑回归进行分析。
在103例MDD患者中,5.8%的患者有任何CA-SI,22.4%的患者有任何SR-SI。在147例BPD患者中,18.4%的患者有任何CA-SI,35.9%的患者有任何SR-SI。MDD患者中任何SR-SI与任何CA-SI之间的一致性为83.5%,BPD患者为83.1%,加权Kappa分别为0.30和0.43。QIDS-SR-16评分、女性性别和≥4年制大学教育与不一致风险增加相关,分别为15.44±4.52分与18.39±3.49分(p = 0.0026)、67%与46%(p = 0.0783)、61%与29%(p = 0.0096)。在MDD和BPD中,不一致与抑郁严重程度呈正相关,相关系数R(2)分别为0.40和0.79,但仅在BPD中与焦虑严重程度呈正相关,R(2)为0.46。
自我报告问卷比临床医生确定的更有可能揭示更高频率和严重程度的自杀意念,这表明将自我报告和临床确定的自杀风险评估与测量抑郁和焦虑严重程度相结合可能对预防自杀是必要的。