Shou Zhangxuan, Jin Xue, Bian Pingda, Li Xiuyang, Chen Jinping
Department of Pharmaceutical Science, Zhejiang Provincial People's Hospital, Hangzhou, China.
Center for Diagnosis and Treatment of Osteoporosis, Zhejiang Provincial People's Hospital, Hangzhou, China.
Geriatr Gerontol Int. 2017 May;17(5):773-778. doi: 10.1111/ggi.12785. Epub 2016 May 2.
The present study was intended to establish the reference intervals of β-C-terminal telopeptide of type I collagen, procollagen type I N-terminal propeptide and osteocalcin for very elderly (aged 80 years or more) Chinese men.
A total of 1316 very elderly Chinese men were recruited into the study, and subjected to a survey of clinical characteristics, measurements of bone mineral density and assays of bone turnover markers. The relationships between underlying diseases and bone turnover markers were investigated, and the reference intervals of β-C-terminal telopeptide of type I collagen, procollagen type I N-terminal propeptide and osteocalcin for very elderly Chinese men were established through defining the central 95% range of all observations.
We found that type 2 diabetes mellitus, chronic obstructive pulmonary disease and abnormal bone mass were associated with serum bone turnover markers (P < 0.01), and thereby identified 208 men without type 2 diabetes mellitus, chronic obstructive pulmonary disease and/or abnormal bone mass as healthy participants from 1316 very elderly Chinese men. The reference intervals for very elderly Chinese men were 0.13-0.63 ng/mL for β-C-terminal telopeptide of type I collagen, 18-94 ng/mL for procollagen type I N-terminal propeptide and 9-28 ng/mL for osteocalcin, respectively. The three turnover markers were moderately correlated to each other (P < 0.001), and all negatively associated with the bone mineral density of three sites (P < 0.05).
We have established the reference intervals of β-C-terminal telopeptide of type I collagen, procollagen type I N-terminal propeptide and osteocalcin for very elderly Chinese men. Geriatr Gerontol Int 2017; 17: 773-778.
本研究旨在建立中国高龄（80岁及以上）男性I型胶原β-羧基端肽、I型前胶原N端前肽和骨钙素的参考区间。
共纳入1316名中国高龄男性参与本研究，对其进行临床特征调查、骨密度测量及骨转换标志物检测。研究潜在疾病与骨转换标志物之间的关系，并通过定义所有观察值的中心95%范围，建立中国高龄男性I型胶原β-羧基端肽、I型前胶原N端前肽和骨钙素的参考区间。
我们发现2型糖尿病、慢性阻塞性肺疾病和骨量异常与血清骨转换标志物相关（P<0.01），从而从1316名中国高龄男性中确定208名无2型糖尿病、慢性阻塞性肺疾病和/或骨量异常的男性为健康参与者。中国高龄男性的参考区间分别为：I型胶原β-羧基端肽0.13 - 0.63 ng/mL、I型前胶原N端前肽18 - 94 ng/mL、骨钙素9 - 28 ng/mL。这三种骨转换标志物相互之间呈中度相关（P<0.001），且均与三个部位的骨密度呈负相关（P<0.05）。
我们建立了中国高龄男性I型胶原β-羧基端肽、I型前胶原N端前肽和骨钙素的参考区间。《老年医学与老年病学国际杂志》2017年；17: 773 - 778。
