Zhang Yu, Jiang Hang, Chen Dushen, Zhang Yanghui
Department of Chemistry, and Shanghai Key Lab of Chemical Assessment and Sustainability, Tongji University, 1239 Siping Road, Shanghai, 200092, P. R. China.
Org Biomol Chem. 2016 May 18;14(20):4585-9. doi: 10.1039/c6ob00674d.
Palladium-catalyzed C-H alkylation reaction with alkylboronic acids has successfully been developed using a removable pyridyldiisopropylsilyl directing group. The amino acid played a crucial role as a ligand in the reaction. The alkylation protocol is also applicable to the coupling of C(sp(3))-H bonds with alkylboronic acids.
使用可去除的吡啶基二异丙基硅基导向基团，成功开发了钯催化的与烷基硼酸的C-H烷基化反应。氨基酸在该反应中作为配体发挥了关键作用。该烷基化方案也适用于C(sp(3))-H键与烷基硼酸的偶联反应。
