多发性硬化症复发期和缓解期的头痛：一项病例对照研究。

Headache in relapse and remission phases of multiple sclerosis: A case-control study.

作者信息

Togha Mansoureh, Abbasi Khoshsirat Nahid, Moghadasi Abdorreza Naser, Mousavinia Faezeh, Mozafari Mohammad, Neishaboury Mohamadreza, Mousavi Seyed Mahmood

机构信息

Headache Research Center, Iranian Center of Neurological Research, Neuroscience Institute AND Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Headache Research Center, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Iran J Neurol. 2016 Jan 5;15(1):1-8.

PMID:27141270

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4852065/

Abstract

BACKGROUND

Headaches are one of the most frequent reasons for pain in multiple sclerosis (MS) individuals. Characterization of headaches and delineating possible relationships with MS-related determinants can ultimately circumvent headaches.

METHODS

In a prospective case-control study, 65 Iranian relapsing-remitting MS (RRMS) patients and 65 healthy controls were recruited during patients' admission for attack-period treatment and asked about characteristics and co-symptoms of headaches they experienced in the preceding week and usage of disease modifying drugs (DMDs) and types of MS attacks were also inquired. The same questions were asked from the same patients 3 months later in a follow-up visit.

RESULTS

A total of 57 patients and 57 controls were included in the final analyses. In total, 26 (45.6%) patients in relapse, 18 (27.7%) controls, and 22 (38.6%) patients in remission reported headaches and only significant difference existed between relapse patients and controls (P = 0.036). In headache prevalence was higher in patients in relapse phase having MS < 3 years compared to relapse patients with more than 3 years of MS (68 vs. 28.1%; P = 0.004). Other variables of interest did not differ among the three groups.

CONCLUSION

The RRMS patients in relapse phase suffer from headaches more than healthy people do.

摘要

背景

头痛是多发性硬化症（MS）患者疼痛的最常见原因之一。对头痛进行特征描述并确定其与MS相关决定因素之间的可能关系，最终可以避免头痛。

方法

在一项前瞻性病例对照研究中，招募了65名伊朗复发缓解型MS（RRMS）患者和65名健康对照，在患者因发作期治疗入院期间进行询问，了解他们在前一周经历的头痛的特征和伴随症状，还询问了疾病修饰药物（DMDs）的使用情况以及MS发作的类型。3个月后在随访中对同一批患者提出相同问题。

结果

最终分析纳入了57名患者和57名对照。总共有26名（45.6%）复发患者、18名（27.7%）对照和22名（38.6%）缓解期患者报告有头痛，仅复发患者与对照之间存在显著差异（P = 0.036）。MS病程<3年的复发期患者头痛患病率高于病程超过3年的复发患者（68%对28.1%；P = 0.004）。三组之间其他感兴趣的变量没有差异。