Ergün Ufuk, Ozer Gökhan, Sekercan Sine, Artan Elif, Kudiaki Ciğdem, Uçler Serap, Coşkun Ozlem, Inan Levent
Department of Neurology, Ankara Education and Research Hospital, Turkey.
Neurologist. 2009 Jul;15(4):212-6. doi: 10.1097/NRL.0b013e3181906fc9.
Primary headaches are known to be associated with multiple sclerosis. We aimed to determine headaches using ICHD-II in different phases of relapsing-remitting multiple sclerosis, and the correlation between headaches and several features of the disease.
Migraine (41.2%) and tension-type headaches (20.6%) were the most common headaches in remission, and primary stabbing headache (PSH) (27.8%) was common in the relapsing phase. Although headaches seemed to occur independently of disease duration, extended disability status scale, beck depression inventory scores, and treatments, the total number of headaches was correlated with periventricular lesions (P = 0.03) and tension-type headaches were correlated with spinal lesions in remission (P = 0.02). Total number of headaches was correlated with brain stem lesions in the relapsing phase (P = 0.05).
The high frequency of PSHs in relapse was notable, and, to the best of our knowledge, PSH was not reported in relapsing-remitting multiple sclerosis before. Further studies with larger samples are recommended.
已知原发性头痛与多发性硬化症相关。我们旨在使用国际头痛疾病分类第二版（ICHD-II）确定复发缓解型多发性硬化症不同阶段的头痛情况，以及头痛与该疾病若干特征之间的相关性。
缓解期最常见的头痛类型为偏头痛（41.2%）和紧张型头痛（20.6%），复发期常见原发性刺痛性头痛（PSH）（27.8%）。尽管头痛似乎独立于病程、扩展残疾状态量表、贝克抑郁量表评分及治疗而发生，但头痛总数与脑室周围病变相关（P = 0.03），缓解期紧张型头痛与脊髓病变相关（P = 0.02）。复发期头痛总数与脑干病变相关（P = 0.05）。
复发期PSH的高发生率值得关注，据我们所知，此前在复发缓解型多发性硬化症中未报告过PSH。建议进行更大样本量的进一步研究。
