Tomala Jakub, Kovar Marek
Laboratory of Tumor Immunology, Institute of Microbiology, Academy of Sciences of the Czech Republic , Prague, Czech Republic.
Oncoimmunology. 2015 Nov 3;5(3):e1102829. doi: 10.1080/2162402X.2015.1102829. eCollection 2016 Mar.
The biological activity of IL-2 can be dramatically increased by complexing with anti-IL-2 mAb. Moreover, IL-2/anti-IL-2 mAb immunocomplexes selectively stimulate different subsets of immune cells, depending on the clone of anti-IL-2 mAb that is used. Thus, IL-2/S4B6 mAb complexes strongly stimulate CD122 populations, namely NK and memory CD8 T cells. They also intermediately stimulate T cells. Conversely, IL-2/JES6.1 mAb immunocomplexes have no stimulatory activity for CD122 populations. However, they potently and highly selectively stimulate CD25 cells (i.e., T and activated T cells). IL-2/S4B6 mAb immunocomplexes have also been shown to possess antitumor activity in various mouse tumor models.
通过与抗IL-2单克隆抗体复合,IL-2的生物活性可显著增强。此外,IL-2/抗IL-2单克隆抗体免疫复合物可选择性刺激不同的免疫细胞亚群,这取决于所使用的抗IL-2单克隆抗体的克隆。因此,IL-2/S4B6单克隆抗体复合物强烈刺激CD122群体,即自然杀伤细胞和记忆性CD8 T细胞。它们也中度刺激T细胞。相反,IL-2/JES6.1单克隆抗体免疫复合物对CD122群体没有刺激活性。然而,它们能有效且高度选择性地刺激CD25细胞(即T细胞和活化T细胞)。在各种小鼠肿瘤模型中,IL-2/S4B6单克隆抗体免疫复合物也已显示出具有抗肿瘤活性。