[圣彼得堡和莫斯科医院分离出的凝固酶阴性葡萄球菌的抗生素耐药性]

[Antibiotic Resistance of Coagulase-Negative Staphylococci Isolated at Hospitals of St. Petersburg and Moscow].

作者信息

Gostev V V, Kalinogorskaya O S, Kruglov A N, Sidorenko S V

出版信息

Antibiot Khimioter. 2015;60(9-10):23-8.

Abstract

Antibiotic susceptibility of 119 coagulase-negative staphylococci isolated at hospitals of St. Petersburg and Moscow was investigated and estimated at the local laboratories as oxacillin resistant. The following species were identified: Staphylococcus epidermidis, S. haemolyticus, S. hominis, S.capitis, S. simulans, S. pettenkoferi, S. lentus, S. carnosus and S. warneri. The oxacillin resistance was confirmed in 79.8% of the isolates. The frequency of the associated resistance to non-beta-lactams was much higher in the oxacillin resistant isolates vs. the oxacillin susceptible ones. When the CLSI and EUCAST susceptibility criteria were used, 1-3% difference in the resistance levels was recorded. Among the oxacillin resistant isolates the frequency of resistance to gentamicin, ciprofloxacin, erythromycin, moxifloxacin, tetracycline and clindamycin equaled 90, 88, 88, 63, 43 and 26% respectively. Two linezolid resistant isolates of S. epidermidis with lower susceptibility to tedizolid were isolated. Eight isolates of S. epidermidis showed lower resistance to mupirocin. The MIC of ceftarolin for oxacillin resistant coagulase-negative staphylococci varied from 0.5 to 2.0 mcg/ml, while for the oxacillin susceptible ones it was lower than 0.25 mcg/ml. No resistance to tigecyclin and vancomycin was observed.

摘要

对从圣彼得堡和莫斯科医院分离出的119株凝固酶阴性葡萄球菌的抗生素敏感性进行了调查，并在当地实验室评估为对苯唑西林耐药。鉴定出以下菌种：表皮葡萄球菌、溶血葡萄球菌、人葡萄球菌、头葡萄球菌、模仿葡萄球菌、佩滕科费尔葡萄球菌、缓慢葡萄球菌、肉葡萄球菌和沃纳葡萄球菌。79.8%的分离株证实对苯唑西林耐药。与苯唑西林敏感株相比，苯唑西林耐药株对非β-内酰胺类抗生素的联合耐药频率要高得多。当使用CLSI和EUCAST药敏标准时，耐药水平记录有1%-3%的差异。在苯唑西林耐药株中，对庆大霉素、环丙沙星、红霉素、莫西沙星、四环素和克林霉素的耐药频率分别为90%、88%、88%、63%、43%和26%。分离出两株对泰地唑胺敏感性较低的耐利奈唑胺表皮葡萄球菌。八株表皮葡萄球菌对莫匹罗星的耐药性较低。头孢洛林对苯唑西林耐药的凝固酶阴性葡萄球菌的MIC值在0.5至2.0 mcg/ml之间，而对苯唑西林敏感的菌株则低于0.25 mcg/ml。未观察到对替加环素和万古霉素的耐药性。