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美国重症监护病房中的菌血症

Bacteremia in an American Intensive Care Unit.

作者信息

Strong Cameron, Cosiano Michael, Cabezas Melanie, Barwatt J W, Tillekeratne L Gayani

机构信息

Department of Medicine, Duke University School of Medicine, Durham, NC, USA.

Department of Psychiatry, Duke University School of Medicine, Durham, NC, USA.

出版信息

Case Rep Infect Dis. 2021 Sep 29;2021:5235691. doi: 10.1155/2021/5235691. eCollection 2021.

Abstract

Coagulase-negative staphylococci (CoNS) are considered the most common cause of nosocomial bloodstream infections; yet, these species are frequently designated as contaminants in the absence of systemic signs and symptoms of infection. Immunocompromised patients or those with prosthetic devices are at increased risk for clinically significant bacteremia. With the advent of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) in clinical practice, there has been improved specificity of CoNS isolate identification and further elucidation of underrecognized pathogenic species. was a novel CoNS species first identified in 2002 and thought to be misdiagnosed as other CoNS due to limitations in biochemical identification. There is increasing identification of isolates; however, there are limited case reports of clinically significant bacteremia and no reported cases within the United States. We present the first known case of from an American intensive care unit.

摘要

凝固酶阴性葡萄球菌(CoNS)被认为是医院血流感染最常见的病因;然而,在没有感染的全身症状和体征时,这些菌种常被认定为污染物。免疫功能低下的患者或植入假体装置的患者发生具有临床意义菌血症的风险增加。随着基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)在临床实践中的出现,CoNS分离株鉴定的特异性有所提高,并且对未被充分认识的致病菌种有了进一步的阐明。[具体菌种名称]是2002年首次鉴定出的一种新型CoNS菌种,由于生化鉴定的局限性,曾被认为误诊为其他CoNS。[具体菌种名称]分离株的鉴定越来越多;然而,具有临床意义的[具体菌种名称]菌血症的病例报告有限,美国境内尚无报告病例。我们报告了美国重症监护病房首例已知的[具体菌种名称]病例。

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