Minuk G Y, Baruch Y
Section of Hepatology, Department of Medicine, University of Manitoba, Winnipeg, Canada.
Liver Unit, The Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Med Hypotheses. 2016 Jun;91:24-27. doi: 10.1016/j.mehy.2016.04.011. Epub 2016 Apr 8.
Accumulated data to date do not entirely explain the; propensity of the hepatitis B virus (HBV) to cause chronic infections in newborns; failure of antiviral agents to resolve infections or precise mechanism whereby HBV causes hepatocellular carcinoma (HCC). Based on the increased numbers of hepatic stem/progenitor cells (HPCs) present within the neonatal liver, the refractoriness of these cells to the effects of interferons and xenobiotics and their ability to undergo malignant transformation, we hypothesize that HBV infection of HPCs could explain these and perhaps other clinical features of chronic HBV.
迄今为止积累的数据并不能完全解释乙肝病毒（HBV）在新生儿中引发慢性感染的倾向、抗病毒药物无法消除感染的原因，也无法解释HBV引发肝细胞癌（HCC）的精确机制。基于新生儿肝脏中存在的肝干细胞/祖细胞（HPCs）数量增加、这些细胞对干扰素和外源性物质作用的难治性以及它们发生恶性转化的能力，我们推测HPCs的HBV感染可以解释慢性HBV的这些以及其他可能的临床特征。
