Aziz Zariah A, Lee Yvonne Yl, Sidek Norsima Nazifah, Ngah Bahari Awang, Looi Irene, Hanip Md Rafia, Basri Hamidon B
a Department of Neurology and Clinical Research Centre , Hospital Sultanah Nur Zahirah , Kuala Terengganu , Malaysia.
b Health and Value, Pfizer Malaysia , Level 10 & 11, Wisma Averis , Kuala Lumpur , Malaysia.
Neurol Res. 2016 May;38(5):406-13. doi: 10.1080/01616412.2016.1178948. Epub 2016 May 4.
Gender as an independent predictor in stroke has been well documented. However, data on gender differences among first-ever ischemic stroke in developing country are limited. We aim to describe gender effects on clinical characteristics, thrombolysis treatment received, and outcomes of patients with first-ever ischemic stroke.
Data were extracted from the prospective multiethnic stroke registry, National Neurology Registry (NNEUR). Descriptive analysis and logistic regression were performed.
A total of 4762 first-ever ischemic stroke patients admitted to 13 government hospitals from July 2009 to June 2015 were available for this study. Slightly over half were male (55.1%), and they were 1.7 years younger than female (mean age, 63.6 versus 61.9 years, p < 0.001). Gender-age-adjusted incidence was observed to be higher in females (66.7 per 100,000) compared to males (57.4 per 100,000). First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. Female experienced significantly poorer functional outcome and greater 30-day in-hospital mortality compared to male. In subgroup analysis, only 31 (0.65%) patients were treated with thrombolysis.
First-ever ischemic stroke incidence increased by 24.3 and 11.2% among female and male annually. There were distinct symptoms at hospital presentation between genders. All our patients discharged home regardless of genders. In summary, Malaysian female first-ever ischemic stroke was older, present with severe stroke, greater number of risk factors and poorer functional outcome and 30-day in-hospital mortality compared to male.
性别作为中风的独立预测因素已有充分记录。然而，发展中国家首次缺血性中风的性别差异数据有限。我们旨在描述性别对首次缺血性中风患者临床特征、接受的溶栓治疗及预后的影响。
数据取自前瞻性多民族中风登记处，即国家神经学登记处（NNEUR）。进行了描述性分析和逻辑回归分析。
本研究纳入了2009年7月至2015年6月期间入住13家政府医院的4762例首次缺血性中风患者。略超过一半为男性（55.1%），且他们比女性年轻1.7岁（平均年龄，63.6岁对61.9岁，p<0.001）。经性别-年龄调整后的发病率显示，女性（每10万人中66.7例）高于男性（每10万人中57.4例）。女性和男性首次缺血性中风的发病率每年分别增加24.3%和11.2%。与男性相比，女性的功能预后明显更差，30天内住院死亡率更高。在亚组分析中，仅31例（0.65%）患者接受了溶栓治疗。
女性和男性首次缺血性中风的发病率每年分别增加24.3%和11.2%。不同性别在入院时症状不同。我们所有患者无论性别均出院回家。总之，马来西亚首次缺血性中风的女性患者年龄更大，中风更严重，危险因素更多，功能预后更差，30天内住院死亡率高于男性。
