Fuller S J, Sugden P H
Department of Cardiac Medicine, University of London, England.
FEBS Lett. 1989 Apr 24;247(2):209-12. doi: 10.1016/0014-5793(89)81336-5.
12-O-Tetradecanoylphorbol 13-acetate acutely stimulated the rate of protein synthesis maximally by about 43% in terminally differentiated myocytes freshly isolated from adult rat hearts. Stimulation was rapidly expressed (within 20 min). The relative effects of four phorbol esters on protein synthesis was consistent with a specific effect on protein kinase C. Inhibition of transcription with actinomycin D had no effect on the absolute stimulation of the protein synthesis rate by 12-O-tetradecanoylphorbol 13-acetate. We conclude that protein kinase C may be involved in the regulation of the translational process.
12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯能迅速刺激从成年大鼠心脏新鲜分离出的终末分化心肌细胞中的蛋白质合成速率，使其最大程度地急性增加约43%。刺激作用在20分钟内迅速显现。四种佛波酯对蛋白质合成的相对影响与对蛋白激酶C的特异性作用一致。用放线菌素D抑制转录对12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯对蛋白质合成速率的绝对刺激没有影响。我们得出结论，蛋白激酶C可能参与翻译过程的调节。
