Demkowicz Sebastian, Kozak Witold, Daśko Mateusz, Rachon Janusz
Dept. Organic Chemistry, Faculty of Chemistry, Gdansk University of Technology, Narutowicza 11/12, 80-233 Gdansk, Poland.
Mini Rev Med Chem. 2016;16(17):1359-1373. doi: 10.2174/1389557516666160505120005.
The present mini-review highlights recent developments on antitumor activity of metal-based therapeutics which have been a subject of researches for the last few decades. In 1965, Rosenberg found that during an electrolysis on platinum electrodes a complex of Pt is generated which inhibited to a great extent a binary fission in Escherichia coli bacteria. This discovery started a new chapter in medicinal chemistry and the interesting properties of cisplatin were soon applied in cancer therapy especially in curing genitourinary tumors. However, various side effects limited its use in medical treatment. Since then a great number of other metal-organic complexes based on platinum, palladium, ruthenium, gold, copper, silver, rhodium, osmium, rhenium, iridium and others have been synthesized. Among them, NAMI-A and KP1019 have recently undergone clinical trials. In this review paper we report a detailed account of metal complexes with phosphorus-based ligands which are of particular interest in therapeutics.
本综述重点介绍了金属基治疗剂抗肿瘤活性的最新进展，在过去几十年中，这一直是研究的主题。1965年，罗森伯格发现，在铂电极上进行电解时会生成一种铂络合物，该络合物在很大程度上抑制了大肠杆菌的二元裂变。这一发现开启了药物化学的新篇章，顺铂的有趣特性很快被应用于癌症治疗，尤其是在治疗泌尿生殖系统肿瘤方面。然而，各种副作用限制了其在医学治疗中的应用。从那时起，人们合成了大量基于铂、钯、钌、金、铜、银、铑、锇、铼、铱等的其他金属有机络合物。其中，NAMI-A和KP1019最近已进入临床试验阶段。在这篇综述论文中，我们详细介绍了对治疗特别有意义的含磷配体金属络合物。
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