Selby Thomas P, Lahm George P, Stevenson Thomas M
DuPont Crop Protection, Stine-Haskell Research Center, Newark, DE, USA.
Pest Manag Sci. 2017 Apr;73(4):658-665. doi: 10.1002/ps.4308. Epub 2016 Jun 7.
Anthranilic diamides are an important commercial synthetic class of insecticides (IRAC Group 28) that bind to the ryanodine receptor with selective potency against insect versus mammalian forms of the receptor. The first commercialized diamide, chlorantraniliprole, has exceptional activity against lepidopteran pests. The second anthranilamide product, cyantraniliprole, has excellent cross-spectrum activity against a range of insect orders, including both lepidopteran and hemipteran pests. Here, a retrospective look is presented on the discovery of the class, along with chemistry highlights of the lead evolution to both products. © 2016 Society of Chemical Industry.
邻氨基苯甲酰胺类是一类重要的商业化合成杀虫剂（IRAC第28组），它们与鱼尼丁受体结合，对昆虫形式的受体具有选择性效力，而对哺乳动物形式的受体则不然。首个商业化的二酰胺类杀虫剂氯虫苯甲酰胺对鳞翅目害虫具有卓越活性。第二个邻氨基苯甲酰胺类产品氰虫酰胺对一系列昆虫目具有出色的广谱活性，包括鳞翅目和半翅目害虫。本文回顾了该类杀虫剂的发现历程，以及两种产品先导化合物优化过程中的化学亮点。© 2016化学工业协会。
