Sun Yaqiong, Wu Jie, Cai Hui, Wang Shuyang, Liu Qiaolan, Blot William J, Shu Xiao Ou, Cai Qiuyin
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 1161 21st Avenue South, Nashville, TN, 37232, USA.
Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Cancer Causes Control. 2016 Jun;27(6):831-5. doi: 10.1007/s10552-016-0757-y. Epub 2016 May 4.
No biomarker is available for pancreatic cancer early detection, but a small prospective European study involving 16 cases and 32 controls raised the possibility that anti-Ezrin autoantibodies may be associated with risk of pancreatic cancer. We aimed to validate this finding in a case-control study nested within a prospective study in the USA.
Levels of anti-Ezrin autoantibodies were examined using ELISA in pre-diagnostic plasma samples of 73 cases and 145 matched controls. Paired t test and paired signed rank tests were used to determine the difference between two groups, and conditional logistic regression was used to evaluate the association between anti-Ezrin autoantibody levels and risk of developing pancreatic cancer.
No association was found between levels of anti-Ezrin plasma autoantibodies and subsequent risk of developing pancreatic cancer.
Anti-Ezrin autoantibodies did not appear to be useful as a plasma biomarker for early detection of pancreatic cancer.
目前尚无用于胰腺癌早期检测的生物标志物,但一项涉及16例病例和32例对照的小型欧洲前瞻性研究提出,抗埃兹蛋白自身抗体可能与胰腺癌风险相关。我们旨在在美国一项前瞻性研究中的病例对照研究中验证这一发现。
使用酶联免疫吸附测定法(ELISA)检测73例病例和145例匹配对照的诊断前血浆样本中抗埃兹蛋白自身抗体的水平。采用配对t检验和配对符号秩检验来确定两组之间的差异,并使用条件逻辑回归来评估抗埃兹蛋白自身抗体水平与患胰腺癌风险之间的关联。
未发现抗埃兹蛋白血浆自身抗体水平与随后患胰腺癌的风险之间存在关联。
抗埃兹蛋白自身抗体似乎不能作为胰腺癌早期检测的血浆生物标志物。