雪貂（Mustela putorius furo）的多骨淋巴瘤

Polyostotic Lymphoma in a Ferret (Mustela putorius furo).

作者信息

Long H, di Girolamo N, Selleri P, Palmieri C

机构信息

School of Veterinary Science, The University of Queensland, 4343 Gatton Campus, Gatton, Queensland, Australia.

Clinica per Animali Esotici, Via Sandro Giovannini 51-53, Roma, Italy.

出版信息

J Comp Pathol. 2016 May;154(4):341-4. doi: 10.1016/j.jcpa.2016.03.003. Epub 2016 May 1.

DOI:10.1016/j.jcpa.2016.03.003

PMID:27147110

Abstract

An 8.5-year-old, neutered female ferret (Mustela putorius furo) was presented with tachypnoea, polyuria, polydipsia, anorexia and depression. Radiographs revealed multiple osteolytic lesions of the bone, characterized cytologically by the infiltration of medium- to large-sized lymphocytes. The animal was humanely destroyed and post-mortem examination revealed multifocal masses obliterating the bone marrow of the mandible, right and left humeri and femur, and consisting of an infiltrative population of neoplastic lymphocytes. Immunohistochemical labelling for CD3 and CD79a revealed a CD3-positive neoplastic population. A diagnosis of polyostotic T-cell lymphoma was made, which is the first report of this condition in a ferret.

摘要

一只8.5岁已绝育的雌性雪貂（白鼬）出现呼吸急促、多尿、多饮、厌食和抑郁症状。X光片显示骨骼有多处溶骨性病变，细胞学特征为中到大型淋巴细胞浸润。该动物被实施安乐死，尸检发现多灶性肿块，破坏了下颌骨、左右肱骨和股骨的骨髓，由浸润性肿瘤淋巴细胞群组成。CD3和CD79a的免疫组化标记显示肿瘤细胞群CD3阳性。诊断为多骨型T细胞淋巴瘤，这是雪貂患此病的首例报道。