Rezk Mohamed, Sayyed Tarek, Ellakwa Hamid, Zahran Ahmed, Gamal Awni
a Department of Obstetrics and Gynecology.
b Department of Internal Medicine , and.
Gynecol Endocrinol. 2016 Oct;32(10):844-847. doi: 10.1080/09513590.2016.1179727. Epub 2016 May 5.
To assess metabolic changes in overweight and obese women above 35 years using ethinylestradiol/drosperinone combined contraceptive pills for 36 cycles.
A prospective case-control study over 3 years recruiting 202 overweight and obese women above the age of 35 years who were divided into two groups, study group (n = 90) who received Ethinylestradiol/drospirenone for 36 cycles, and control group (n = 112) to whom intrauterine device was inserted. Recording of the body weight, waist circumference, blood pressure, fasting blood glucose and fasting blood lipids including triglycerides, total cholesterol, low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol before starting the method and repeated at 12, 24 and 36 cycles of use.
No significant change was observed in body weight, waist circumference, blood pressure and fasting blood glucose between the two groups (p > 0.05).There was a significant reduction in triglycerides, total and LDL cholesterol with elevation in HDL cholesterol in the study group after 24 and 36 cycles of use (p < 0.05).
Ethinylestradiol/drospirenone combined contraceptive pills do not alter blood pressure or affect the body weight, with favorable effects on blood lipids in overweight and obese women above the age of 35 years when used for 24-36 cycles.
评估35岁以上超重及肥胖女性使用炔雌醇/屈螺酮复方避孕药36个周期后的代谢变化。
一项为期3年的前瞻性病例对照研究，招募了202名35岁以上的超重及肥胖女性，将其分为两组，研究组（n = 90）接受炔雌醇/屈螺酮治疗36个周期，对照组（n = 112）放置宫内节育器。在开始该方法前记录体重、腰围、血压、空腹血糖和空腹血脂，包括甘油三酯、总胆固醇、低密度脂蛋白（LDL）胆固醇和高密度脂蛋白（HDL）胆固醇，并在使用的第12、24和36个周期重复记录。
两组之间的体重、腰围、血压和空腹血糖均未观察到显著变化（p > 0.05）。研究组在使用24和36个周期后，甘油三酯、总胆固醇和LDL胆固醇显著降低，HDL胆固醇升高（p < 0.05）。
炔雌醇/屈螺酮复方避孕药不会改变血压或影响体重，在35岁以上超重及肥胖女性中使用24 - 36个周期时对血脂有有益影响。
