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盆腔子宫内膜异位症、卵巢巧克力囊肿及复发性卵巢巧克力囊肿对体外受精-胚胎移植/卵胞浆内单精子注射结局的影响

EFFECT OF PELVIC ENDOMETRIOSIS, ENDOMETRIOMAS AND RECURRENT ENDOMETRIOMAS ON IVF-ET/ICSI OUTCOMES.

作者信息

Xing Weijie, Lin Haiyan, Wu Zexuan, Li Yu, Zhang Qingxue

机构信息

Center for Reproductive Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Center for Reproductive Medicine, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou, China.

出版信息

Mater Sociomed. 2016 Apr;28(2):91-4. doi: 10.5455/msm.2016.28.91-94. Epub 2016 Mar 25.

Abstract

INTRODUCTION

Endometriosis, the most common gynecological disorder, is a challenging disease observed in 20% - 40% of subfertile women.

MATERIAL AND METHODS

380 women were divided into four groups. Group A consisted of 176 women with pelvic endometriosis. Group B consisted of 125 women who had previously undergone a laparoscopic endometrioma cystectomy. Group C consisted of 38 women with recurrent endometriomas without aspiration before IVF-ET/ICSI. Group D consisted of 41 women with recurrent endometriomas undergone aspiration before IVF-ET/ICSI.

RESULTS

Baseline FSH level (8.61 ± 3.42 mIU/mL) and total dose of Gn (2337.15 ± 853.00 IU) in Group A were the lowest (p < 0.05). The number of retrieved oocytes in Group B (7.98 ± 5.05) was significantly fewer than those in Group A and D (p < 0.05). The numbers of MII oocytes in Groups A, C and D were significantly larger than that in Group B. The number of retrieved oocytes, high-quality embryos, implantation and pregnancy rates were similar in Groups C and D.

CONCLUSIONS

Pelvic endometriosis had a less adverse effect on ovarian reserve than endometrioma. No advantage was found in transvaginal aspiration for recurrent endometriomas before IVF-ET/ICSI.

摘要

引言

子宫内膜异位症是最常见的妇科疾病,是一种具有挑战性的疾病,在20% - 40%的不孕女性中可见。

材料与方法

380名女性被分为四组。A组由176名患有盆腔子宫内膜异位症的女性组成。B组由125名先前接受过腹腔镜子宫内膜瘤囊肿切除术的女性组成。C组由38名在体外受精 - 胚胎移植/卵胞浆内单精子注射前未进行抽吸的复发性子宫内膜瘤患者组成。D组由41名在体外受精 - 胚胎移植/卵胞浆内单精子注射前进行过抽吸的复发性子宫内膜瘤患者组成。

结果

A组的基线促卵泡激素水平(8.61±3.42 mIU/mL)和促性腺激素总剂量(2337.15±853.00 IU)最低(p<0.05)。B组回收的卵母细胞数量(7.98±5.05)明显少于A组和D组(p<0.05)。A、C和D组的MII期卵母细胞数量明显多于B组。C组和D组回收的卵母细胞数量、优质胚胎数量、着床率和妊娠率相似。

结论

盆腔子宫内膜异位症对卵巢储备的不良影响小于子宫内膜瘤。在体外受精 - 胚胎移植/卵胞浆内单精子注射前,经阴道抽吸复发性子宫内膜瘤没有优势。

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