Department of Obstetrics and Gynecology, Lucina Women & Children Hospital, Kaohsiung, Taiwan.
Taiwan J Obstet Gynecol. 2012 Mar;51(1):66-70. doi: 10.1016/j.tjog.2012.01.013.
The aim of this study was to investigate simultaneous laparoscopy in endometriotic women with infertility undergoing in vitro fertilization (IVF).
Forty-seven infertile patients with endometriosis were enrolled in this retrospective study and underwent IVF cycles in a university affiliated hospital.
The chemical pregnancy, clinical pregnancy and live birth rates were statistically significantly different between patients with minimal or mild stage endometriosis and patients with moderate or severe stage endometriosis, who received simultaneous laparoscopy and modified IVF with a GnRH antagonist protocol. A higher live birth rate was achieved in IVF patients with minimal or mild stage endometriosis combined with laparoscopic treatment, than in patients who received traditional IVF with prior laparoscopic surgery for endometrioma.
Simultaneous laparoscopy combined with a modified IVF (GnRH antagonist) protocol may benefit patients with minimal and mild endometriosis. Traditional GnRH agonist IVF cycles may improve the fecundity rates in women with moderate and severe endometriosis after laparoscopic treatment.
本研究旨在探讨同时进行腹腔镜手术与体外受精(IVF)对患有子宫内膜异位症的不孕患者的影响。
本回顾性研究纳入了 47 名患有子宫内膜异位症的不孕患者,这些患者在一家大学附属医院接受了 IVF 周期治疗。
接受同时进行腹腔镜手术和改良 GnRH 拮抗剂方案 IVF 的轻度或极轻度子宫内膜异位症患者与接受中度或重度子宫内膜异位症患者相比,其化学妊娠率、临床妊娠率和活产率存在显著统计学差异。与单纯接受传统 IVF 联合先前腹腔镜手术治疗子宫内膜瘤的患者相比,轻度或极轻度子宫内膜异位症合并腹腔镜治疗的 IVF 患者的活产率更高。
同时进行腹腔镜手术与改良 IVF(GnRH 拮抗剂)方案可能对轻度和极轻度子宫内膜异位症患者有益。传统 GnRH 激动剂 IVF 周期可能会提高腹腔镜治疗后中度和重度子宫内膜异位症患者的生育能力。