棉酚对人类精子活力的抑制作用：与时间、温度和浓度的关系。

The inhibitory effect of gossypol on human sperm motility: relationship with time, temperature and concentration.

作者信息

Hong C Y, Huang J J, Wu P

机构信息

Department of Medicine, Taiwan Veterans General Hospital, Taipei, Republic of China.

出版信息

Hum Toxicol. 1989 Jan;8(1):49-51. doi: 10.1177/096032718900800109.

DOI:10.1177/096032718900800109

PMID:2714811

Abstract

The inhibitory effect of gossypol acetic acid on human sperm motility was studied with a transmembrane migration method. Gossypol decreased sperm motility after it had been incubated with semen for more than 15 min. However, when sperm motility was evaluated immediately after semen had been mixed with gossypol, no inhibitory effect could be found. We consider that the sperm immobilizing potency of gossypol is much less than our previously studied sperm immobilizing agents. It is unlikely that gossypol can be developed as a vaginal spermicide. The importance of time course in the pharmacological study of sperm motility is emphasized in this study.

摘要

采用跨膜迁移法研究了醋酸棉酚对人精子活力的抑制作用。棉酚与精液孵育超过15分钟后可降低精子活力。然而，当精液与棉酚混合后立即评估精子活力时，未发现抑制作用。我们认为棉酚的精子固定效力远低于我们之前研究的精子固定剂。棉酚不太可能被开发为阴道杀精剂。本研究强调了时间进程在精子活力药理学研究中的重要性。