Zhang Naixin, Kima Peter E
Department of Microbiology and Cell Science, University of Florida , Gainesville, FL , USA.
Front Immunol. 2016 Apr 18;7:146. doi: 10.3389/fimmu.2016.00146. eCollection 2016.
Protein kinases play important roles in the regulation of cellular activities. In cells infected by pathogens, there is an increasing appreciation that dysregulated expression of protein kinases promotes the success of intracellular infections. In Leishmania-infected cells, expression and activation of protein kinases, such as the mitogen-activated protein kinases, kinases in the PI3-kinase signaling pathway, and kinases in the NF-κB-signaling pathway, are modulated in some manner. Several recent reviews have discussed our current understanding of the roles of these kinases in Leishmania infections. Apart from the kinases in the pathways enumerated above, there are other host cell protein kinases that are activated during the Leishmania infection of mammalian cells whose roles also appear to be significant. This review discusses recent observations on the Abl family of protein kinases and the protein kinase regulated by RNA in Leishmania infections.
蛋白激酶在细胞活动的调节中发挥着重要作用。在被病原体感染的细胞中，人们越来越认识到蛋白激酶表达失调会促进细胞内感染的成功。在利什曼原虫感染的细胞中，诸如丝裂原活化蛋白激酶、PI3激酶信号通路中的激酶以及NF-κB信号通路中的激酶等蛋白激酶的表达和激活会以某种方式受到调节。最近的几篇综述讨论了我们目前对这些激酶在利什曼原虫感染中作用的理解。除了上述通路中的激酶外，还有其他宿主细胞蛋白激酶在利什曼原虫感染哺乳动物细胞的过程中被激活，其作用似乎也很重要。本综述讨论了关于利什曼原虫感染中Abl蛋白激酶家族和RNA调节的蛋白激酶的最新观察结果。
