Department of Chemistry and Biochemistry, Montclair State University, 1 Normal Avenue, Montclair, NJ 07043, United States.
Bioorg Med Chem Lett. 2012 Nov 15;22(22):6788-93. doi: 10.1016/j.bmcl.2012.09.044. Epub 2012 Sep 24.
Protein kinases are becoming widely investigated targets for treatment of protozoal parasitic tropical diseases such as malaria and leishmaniasis. The search for potent, selective inhibitors of these parasitic enzymes has been aided by the extensive variety of structures prepared for human diseases. Genomic approaches to target identification and validation have aided the search. Substantial progress has been made and research is continuing to expand in an effort to find safe, effective drug candidates for these difficult to treat and widespread diseases.
蛋白激酶正在成为治疗疟疾和利什曼病等热带寄生虫病的广泛研究目标。由于为人类疾病制备了大量的结构，这些寄生虫酶的有效、选择性抑制剂的寻找得到了帮助。基因组方法在目标鉴定和验证方面提供了帮助。已经取得了重大进展，并且正在继续努力寻找安全、有效的候选药物，以治疗这些难以治疗且广泛存在的疾病。
