Temkin Sarah M, Minasian Lori, Noone Anne-Michelle
Division of Cancer Prevention, National Cancer Institute , Bethesda, MD , USA.
Division of Cancer Control and Population Sciences, National Cancer Institute , Bethesda, MD , USA.
Front Oncol. 2016 Apr 14;6:89. doi: 10.3389/fonc.2016.00089. eCollection 2016.
Population-level cancer incidence rates are one measure to estimate the cancer burden. The goal is to provide information on trends to measure progress against cancer at the population level and identify emerging patterns signifying increased risk for additional research and intervention. Endometrial cancer is the most common of the gynecologic malignancies but capturing the incidence of disease among women at risk (i.e., women with a uterus) is challenging and not routinely published. Decreasing rates of hysterectomy increase the number of women at risk for disease, which should be reflected in the denominator of the incidence rate calculation. Furthermore, hysterectomy rates vary within the United States by multiple factors including geographic location, race, and ethnicity. Changing rates of hysterectomy are important to consider when looking at endometrial cancer trends. By correcting for hysterectomy when calculating incidence rates of cancers of the uterine corpus, many of the disparities that have been assumed for this disease are diminished.
人群层面的癌症发病率是估计癌症负担的一项指标。目的是提供有关趋势的信息，以衡量在人群层面抗击癌症的进展，并识别表明风险增加的新出现模式，以便进行更多研究和干预。子宫内膜癌是最常见的妇科恶性肿瘤，但要掌握有患病风险女性（即有子宫的女性）的疾病发病率具有挑战性，且未定期公布。子宫切除率的下降增加了有疾病风险的女性数量，这应反映在发病率计算的分母中。此外，美国国内子宫切除率因地理位置、种族和民族等多种因素而有所不同。在研究子宫内膜癌趋势时，子宫切除率的变化很重要。通过在计算子宫体癌发病率时校正子宫切除情况，许多原本认为的该疾病差异就会减小。
