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过氧化物酶体增殖物激活受体γ（PPAR-γ）激动剂和血管紧张素受体拮抗剂对糖尿病和/或高血压大鼠主动脉对α受体激动剂收缩反应的影响。

Effects of a PPAR-gamma receptor agonist and an angiotensin receptor antagonist on aortic contractile responses to alpha receptor agonists in diabetic and/or hypertensive rats.

作者信息

Tugrul Ibrahim, Dost Turhan, Demir Omer, Gokalp Filiz, Oz Ozlem, Girit Necip, Birincioglu Mustafa

机构信息

Department of Medical Pharmacology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey. Email:

Department of Medical Pharmacology, Faculty of Medicine, Adnan Menderes University, Aydin, Turkey.

出版信息

Cardiovasc J Afr. 2016;27(3):164-169. doi: 10.5830/CVJA-2015-080. Epub 2016 May 4.

DOI:10.5830/CVJA-2015-080
PMID:27149161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5101471/
Abstract

AIM

The aim of this study was to investigate the effects of pioglitazone and losartan pre-treatment on the aortic contractile response to the alpha-1 agonist, phenylephrine, and the alpha-2 agonist, clonidine, in L-NAME-induced hypertensive, STZ-induced diabetic, and hypertensive diabetic rats.

METHODS

Male Wistar rats were randomly allocated to four groups: control, diabetic (DM), hypertensive (HT) and hypertensive diabetic (HT + DM) groups. Three weeks after drug application, in vitro dose-response curves to phenylephrine (Phe) (10-10 M) and clonidine (Clo) (10-10 M) were recorded in aortic rings in the absence (control) and presence of pioglitazone (10 µM) and/or losartan (10 µM).

RESULTS

Pioglitazone and losartan caused a shift to the right in contractile response to phenylephrine in all groups. The sensitivity of the aortic rings to phenylephrine was decreased in the presence of pioglitazone and/or losartan in all groups. The contractile response of clonidine decreased in the presence of pioglitazone and/or losartan in the control, HT and DM groups.

CONCLUSION

The sensitivity of aortic rings to alpha-1 and alpha-2 adrenoceptors was decreased in the presence of pioglitazone and/or losartan in diabetic and hypertensive rats. Concomitant use of PPAR-gamma agonists, thiazolidinediones, and angiotensin receptor blockers may be effective treatment for diabetes and hypertension.

摘要

目的

本研究旨在探讨吡格列酮和氯沙坦预处理对L-NAME诱导的高血压、STZ诱导的糖尿病以及高血压糖尿病大鼠主动脉对α-1激动剂去氧肾上腺素和α-2激动剂可乐定的收缩反应的影响。

方法

将雄性Wistar大鼠随机分为四组：对照组、糖尿病组（DM）、高血压组（HT）和高血压糖尿病组（HT + DM）。给药三周后，在无（对照）以及有吡格列酮（10 μM）和/或氯沙坦（10 μM）存在的情况下，记录主动脉环对去氧肾上腺素（Phe）（10-10 M）和可乐定（Clo）（10-10 M）的体外剂量反应曲线。

结果

吡格列酮和氯沙坦使所有组对去氧肾上腺素的收缩反应向右移位。在所有组中，存在吡格列酮和/或氯沙坦时，主动脉环对去氧肾上腺素的敏感性降低。在对照组、HT组和DM组中，存在吡格列酮和/或氯沙坦时，可乐定的收缩反应降低。

结论

在糖尿病和高血压大鼠中，存在吡格列酮和/或氯沙坦时，主动脉环对α-1和α-2肾上腺素能受体的敏感性降低。同时使用PPAR-γ激动剂、噻唑烷二酮类药物和血管紧张素受体阻滞剂可能是治疗糖尿病和高血压的有效方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/e23be6893bc8/cvja-27-167-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/460d6a938f69/cvja-27-166-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/3587eb090073/cvja-27-166-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/d60118fe3734/cvja-27-166-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/58609f01c2ac/cvja-27-166-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/87880326dd67/cvja-27-167-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/117877cef00d/cvja-27-167-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/7ea3c9dc584e/cvja-27-167-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/e23be6893bc8/cvja-27-167-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/460d6a938f69/cvja-27-166-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/3587eb090073/cvja-27-166-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/58609f01c2ac/cvja-27-166-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/87880326dd67/cvja-27-167-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/117877cef00d/cvja-27-167-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/7ea3c9dc584e/cvja-27-167-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/404f/5101471/e23be6893bc8/cvja-27-167-g008.jpg

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