双肼屈嗪性肝炎康复患者中安替比林和磺胺二甲嘧啶的药代动力学

Kinetics of antipyrine and sulfamethazine in patients recovered from dihydralazine-hepatitis.

作者信息

Siegmund W, Franke G, Baumgarten R, Fengler J D, Krüger R, Reichardt R

机构信息

Department of Clinical Pharmacology, University of Greifswald, GDR.

出版信息

Int J Clin Pharmacol Ther Toxicol. 1989 Apr;27(4):165-9.

PMID:2714917

Abstract

Pharmacokinetic studies with sulfamethazine (500 mg) and antipyrine (15 mg/kg) were performed in 27 hypertonic patients (16 females, 11 males, 37-78 years) who had recovered from a dihydralazine-induced hepatitis, and 21 patients with essential hypertension (13 females, 8 males, 18-74 years) treated with antihypertonics excluding dihydralazine. 20 patients of the hepatitis group (74%) and 12 patients of the control group (57%) were slow acetylators. With regard to the pharmacokinetic parameters no differences were found in both slow and rapid acetylators between the sulfamethazine group and the antipyrine group.

摘要

对27例从肼屈嗪诱发的肝炎中康复的高渗患者（16例女性，11例男性，37 - 78岁）以及21例接受除肼屈嗪外的抗高血压药治疗的原发性高血压患者（13例女性，8例男性，18 - 74岁）进行了磺胺二甲嘧啶（500毫克）和安替比林（15毫克/千克）的药代动力学研究。肝炎组的20例患者（74%）和对照组的12例患者（57%）为慢乙酰化者。在药代动力学参数方面，磺胺二甲嘧啶组和安替比林组的慢乙酰化者和快乙酰化者之间均未发现差异。