病毒抑制的关系动态与伴侣信念：对感染艾滋病毒/艾滋病男性伴侣的纵向研究（二人项目）
Relationship Dynamics and Partner Beliefs About Viral Suppression: A Longitudinal Study of Male Couples Living with HIV/AIDS (The Duo Project).
作者信息
Conroy Amy A, Gamarel Kristi E, Neilands Torsten B, Dilworth Samantha E, Darbes Lynae A, Johnson Mallory O
机构信息
Department of Medicine, Center for AIDS Prevention Studies, University of California - San Francisco, 550 16th Street 3rd Floor, San Francisco, CA, USA.
Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA.
出版信息
AIDS Behav. 2016 Jul;20(7):1572-83. doi: 10.1007/s10461-016-1423-9.
Accurate beliefs about partners' viral suppression are important for HIV prevention and care. We fit multilevel mixed effects logistic regression models to examine associations between partners' viral suppression beliefs and objective HIV RNA viral load tests, and whether relationship dynamics were associated with accurate viral suppression beliefs over time. Male couples (N = 266 couples) with at least one HIV-positive partner on antiretroviral therapy completed five assessments over 2 years. Half of the 407 HIV-positive partners were virally suppressed. Of the 40 % who had inaccurate viral load beliefs, 80 % assumed their partner was suppressed. The odds of having accurate viral load beliefs decreased over time (OR = 0.83; p = 0.042). Within-couple differences in dyadic adjustment (OR = 0.66; p < 0.01) and commitment (OR = 0.82; p = 0.022) were negatively associated with accurate viral load beliefs. Beliefs about a partner's viral load may factor into sexual decision-making and social support. Couple-based approaches are warranted to improve knowledge of partners' viral load.
对伴侣病毒抑制情况的准确认知对于艾滋病病毒的预防和护理至关重要。我们采用多层次混合效应逻辑回归模型来研究伴侣对病毒抑制的认知与客观的艾滋病病毒核糖核酸病毒载量检测之间的关联，以及随着时间推移关系动态是否与准确的病毒抑制认知相关。有至少一名接受抗逆转录病毒治疗的艾滋病病毒呈阳性伴侣的男性伴侣（N = 266对）在两年内完成了五次评估。407名艾滋病病毒呈阳性的伴侣中有一半病毒得到抑制。在病毒载量认知不准确的40%的人中，80%认为其伴侣病毒得到了抑制。随着时间推移，拥有准确病毒载量认知的几率降低（比值比 = 0.83；p = 0.042）。二元调适（比值比 = 0.66；p < 0.01）和承诺（比值比 = 0.82；p = 0.022）方面的伴侣内部差异与准确的病毒载量认知呈负相关。对伴侣病毒载量的认知可能会影响性决策和社会支持。有必要采用基于伴侣关系的方法来提高对伴侣病毒载量的了解。
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