Chechi K, Richard D
Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec (CRIUCPQ), Université Laval , Quebec, QC, Canada.
Int J Obes Suppl. 2015 Aug;5(Suppl 1):S28-34. doi: 10.1038/ijosup.2015.8. Epub 2015 Aug 4.
Epicardial adipose tissue is a unique fat depot around the heart that shares a close anatomic proximity and vascular supply with the myocardium and coronary arteries. Its accumulation around the heart, measured using various imaging modalities, has been associated with the onset and progression of coronary artery disease in humans. Epicardial adipose tissue is also the only fat depot around the heart that is known to express uncoupling protein 1 at both mRNA and protein levels in the detectable range. Recent advances have further indicated that human epicardial fat exhibits beige fat-like features. Here we provide an overview of the physiological and pathophysiological relevance of human epicardial fat, and further discuss whether its thermogenic properties can serve as a target for the therapeutic management of coronary heart disease in humans.
心外膜脂肪组织是心脏周围独特的脂肪库，与心肌和冠状动脉在解剖位置上紧密相邻且血管供应相同。通过各种成像方式测量，其在心脏周围的积聚与人类冠状动脉疾病的发生和进展有关。心外膜脂肪组织也是心脏周围唯一已知在可检测范围内mRNA和蛋白质水平均表达解偶联蛋白1的脂肪库。最近的进展进一步表明，人类心外膜脂肪具有米色脂肪样特征。在此，我们概述了人类心外膜脂肪的生理和病理生理相关性，并进一步讨论其产热特性是否可作为人类冠心病治疗管理的靶点。
