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各州入学及教育规定对人乳头瘤病毒疫苗接种覆盖率的影响:2009 - 2013年全国青少年免疫调查分析

Impact of school-entry and education mandates by states on HPV vaccination coverage: Analysis of the 2009-2013 National Immunization Survey-Teen.

作者信息

Perkins Rebecca B, Lin Mengyun, Wallington Sherrie F, Hanchate Amresh D

机构信息

a Boston University School of Medicine/Boston Medical Center , Boston , MA , USA.

b Lombardi Comprehensive Cancer Center/Georgetown University Medical Center , Washington DC , USA.

出版信息

Hum Vaccin Immunother. 2016 Jun 2;12(6):1615-22. doi: 10.1080/21645515.2016.1150394. Epub 2016 May 6.

Abstract

OBJECTIVE

To determine the effectiveness of existing school entry and education mandates on HPV vaccination coverage, we compared coverage among girls residing in states and jurisdictions with and without education and school-entry mandates. Virginia and the District of Columbia enacted school entry mandates, though both laws included liberal opt-out provisions. Ten additional states had mandates requiring distribution of education to parents or provision of education within school curricula.

METHODS

Using data from the National Immunization Survey-Teen from 2009-2013, we estimated multilevel logistic regression models to compare coverage with HPV vaccines for girls ages 13-17 residing in states and jurisdictions with and without school entry and education mandates, adjusting for demographic factors, healthcare access, and provider recommendation.

RESULTS

Girls residing in states and jurisdictions with HPV vaccine school entry mandates (DC and VA) and education mandates (LA, MI, CO, IN, IA, IL, NJ, NC, TX, and WA) did not have higher HPV vaccine series initiation or completion than those living in states without mandates for any year (2009-2013). Similar results were seen when comparing girls ages 13-14 to those ages 15-17, and after adjustment for known covariates of vaccination.

CONCLUSIONS

States and jurisdictions with school-entry and education mandates do not currently have higher HPV vaccination coverage than states without such legislation. Liberal opt-out language in existing school entry mandates may weaken their impact. Policy-makers contemplating legislation to improve vaccination coverage should be aware of the limitations of existing mandates.

摘要

目的

为了确定现有的入学及教育规定对人乳头瘤病毒(HPV)疫苗接种覆盖率的有效性,我们比较了居住在有和没有教育及入学规定的州和辖区的女孩的疫苗接种覆盖率。弗吉尼亚州和哥伦比亚特区颁布了入学规定,不过这两项法律都包含宽松的豁免条款。另外还有10个州有规定,要求向家长发放教育资料或在学校课程中提供相关教育。

方法

利用2009 - 2013年全国青少年免疫调查的数据,我们估计了多级逻辑回归模型,以比较居住在有和没有入学及教育规定的州和辖区的13 - 17岁女孩的HPV疫苗接种覆盖率,并对人口因素、医疗服务可及性和提供者建议进行了调整。

结果

居住在有HPV疫苗入学规定(哥伦比亚特区和弗吉尼亚州)和教育规定(路易斯安那州、密歇根州、科罗拉多州、印第安纳州、爱荷华州、伊利诺伊州、新泽西州、北卡罗来纳州、得克萨斯州和华盛顿州)的州和辖区的女孩,在任何一年(2009 - 2013年)的HPV疫苗系列接种起始率或完成率都不比没有规定的州的女孩高。在比较13 - 14岁女孩和15 - 17岁女孩时,以及在对已知的疫苗接种协变量进行调整后,也出现了类似的结果。

结论

有入学及教育规定的州和辖区目前的HPV疫苗接种覆盖率并不比没有此类立法的州高。现有入学规定中宽松的豁免措辞可能会削弱其影响。考虑通过立法提高疫苗接种覆盖率的政策制定者应该意识到现有规定的局限性。

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