Departments of 1 Neurologic Surgery and.
Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah.
J Neurosurg. 2017 Mar;126(3):933-937. doi: 10.3171/2016.2.JNS151051. Epub 2016 May 6.
Lipomatosis of nerve (LN) is a rare disorder of peripheral nerves that produces proliferation of interfascicular adipose tissue. It may be associated with soft-tissue and bony overgrowth within the affected nerve territory. LN has been almost exclusively reported in appendicular peripheral nerves; the median nerve at the wrist and palm is among the most common locations. The authors present a new pattern of LN that shows circumferential proliferation of fat around the epineurium of the nerve. They believe that this case and the two other documented examples in the literature (also affecting cervical and thoracic spinal nerves) share the same new pattern of LN. Defining the full spectrum of adipose lesions of the nerve and establishing a cause-effect relationship with nerve-territory overgrowth disorders may offer options for future management through targeted nerve lesioning.
神经脂肪瘤病（LN）是一种罕见的周围神经疾病，会导致神经束间脂肪组织增生。它可能与受累神经区域内的软组织和骨过度生长有关。LN 几乎仅在四肢周围神经中报道；腕部和手掌的正中神经是最常见的部位之一。作者提出了一种新的 LN 模式，即神经外膜周围的脂肪呈环状增生。他们认为，这种情况和文献中记录的另外两例（同样影响颈椎和胸段脊神经）具有相同的 LN 新模式。明确神经脂肪病变的全貌，并与神经区域过度生长疾病建立因果关系，可能为通过靶向神经病变进行未来治疗提供选择。
