Tindall B, Finlayson R, Mutimer K, Billson F A, Munro V F, Cooper D A
Centre for Immunology, St. Vincent's Hospital, Sydney, NSW, Australia.
J Am Acad Dermatol. 1989 Apr;20(4):587-91. doi: 10.1016/s0190-9622(89)70068-2.
This report concerns three patients with human immunodeficiency virus (HIV) infection in whom malignant melanoma developed. One patient had metastatic malignant melanoma, one had iris melanoma, and one had a single skin melanoma. All three had lower absolute numbers of CD4+ cells than a control group, and the severity of their disease was inversely proportional to the absolute number of CD4+ cells. This report suggests an association between the immunodeficiency resulting from HIV infection and the development of malignant melanoma.
本报告涉及3例感染人类免疫缺陷病毒（HIV）并发生恶性黑色素瘤的患者。1例患有转移性恶性黑色素瘤，1例患有虹膜黑色素瘤，1例患有单发皮肤黑色素瘤。这3例患者的CD4+细胞绝对计数均低于对照组，且其疾病严重程度与CD4+细胞绝对计数呈负相关。本报告提示，HIV感染所致免疫缺陷与恶性黑色素瘤的发生之间存在关联。
