激活素A在子痫前期内皮细胞功能障碍发病机制中的作用。
Role of activin A in the pathogenesis of endothelial cell dysfunction in preeclampsia.
作者信息
Hobson Sebastian R, Acharya Rutu, Lim Rebecca, Chan Siow Teng, Mockler Joanne, Wallace Euan M
机构信息
Department of Obstetrics and Gynaecology, Monash University, 246 Clayton Road, Clayton, VIC 3168, Australia; The Ritchie Centre, Hudson Institute of Medical Research, Monash University, Clayton, VIC 3168, Australia; Monash Women's Services, Monash Health, Clayton, VIC 3168, Australia.
The Ritchie Centre, Hudson Institute of Medical Research, Monash University, Clayton, VIC 3168, Australia.
出版信息
Pregnancy Hypertens. 2016 Apr;6(2):130-3. doi: 10.1016/j.preghy.2016.03.001. Epub 2016 Mar 31.
Circulating markers for endothelial activation such as endothelin-1 (ET-1), ICAM-1 and VCAM-1 are elevated in women with preeclampsia. Using human umbilical vein endothelial cells (HUVECs) as an in vitro model of the maternal vasculature, we show that activin A and preeclamptic serum upregulate ET-1, ICAM-1, and VCAM-1 in HUVECs. Further, we show that follistatin, a specific binding protein for activin, mitigates the upregulation of ET-1, ICAM-1 and VCAM-1 in HUVECs exposed to either activin A or preeclamptic serum. These data are consistent with activin A contributing to the pathophysiology of preeclampsia and suggest that therapies targeting activin signalling are worth exploring.
内皮素 -1（ET -1）、细胞间黏附分子 -1（ICAM -1）和血管细胞黏附分子 -1（VCAM -1）等内皮激活的循环标志物在子痫前期女性中升高。我们将人脐静脉内皮细胞（HUVECs）作为母体血管系统的体外模型，发现激活素A和子痫前期血清会上调HUVECs中的ET -1、ICAM -1和VCAM -1。此外，我们还发现，激活素的特异性结合蛋白卵泡抑素可减轻暴露于激活素A或子痫前期血清的HUVECs中ET -1、ICAM -1和VCAM -1的上调。这些数据与激活素A参与子痫前期的病理生理过程一致，并表明针对激活素信号传导的疗法值得探索。
Zotero 插件