玉家族植物同源结构域指蛋白1（JADE1）的结构、功能及调控
Structure, function and regulation of jade family PHD finger 1 (JADE1).
作者信息
Panchenko Maria V
机构信息
Department of Pathology and Laboratory Medicine, Boston University School of Medicine, United States.
出版信息
Gene. 2016 Sep 1;589(1):1-11. doi: 10.1016/j.gene.2016.05.002. Epub 2016 May 4.
Abstract
The family of JADE proteins includes three paralogues encoded by individual genes and designated PHF17 (JADE1), PHF16 (JADE2), and PHF15 (JADE3). All three JADE proteins bear in tandem two Plant Homeo-domains (PHD) which are zinc finger domains. This review focuses on one member of the JADE family, JADE1. Studies addressing the biochemical, cellular and biological role of JADE1 are discussed. Recent discoveries of JADE1 function in the regulation of the epithelial cell cycle with potential relevance to disease are presented. Unresolved questions and future directions are formulated.
摘要
玉蛋白家族包括由单个基因编码的三个旁系同源物，分别命名为PHF17（玉蛋白1）、PHF16（玉蛋白2）和PHF15（玉蛋白3）。所有这三种玉蛋白都串联有两个植物同源结构域（PHD），它们是锌指结构域。本综述聚焦于玉蛋白家族的一个成员——玉蛋白1。文中讨论了关于玉蛋白1的生化、细胞和生物学作用的研究。介绍了玉蛋白1在调节上皮细胞周期方面的功能的最新发现，这些发现可能与疾病相关。还提出了未解决的问题和未来的研究方向。
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