a Department of Infectious Diseases , Hospital Clínic of Barcelona , Barcelona , Spain.
b Department of Pharmacology and Toxicology , Hospital Clínic of Barcelona , Barcelona , Spain.
Expert Opin Pharmacother. 2016 Jun;17(9):1183-7. doi: 10.1080/14656566.2016.1182154. Epub 2016 May 11.
The major concern of linezolid is the adverse events. High linezolid trough serum concentration (Cmin) has been associated with toxicity. The aim of this study was to analyze factors associated with high Cmin.
Main clinical characteristics of 104 patients treated with 600 mg/12 hours of linezolid were retrospectively reviewed. Samples were obtained just before the next dose after at least three doses and within the first 8 days of treatment. High Cmin was considered when it was >8 mg/L. Univariate and multivariate analysis were performed.
34.6% patients had a Cmin >8 mg/L, and they were older and had more frequently an estimated glomerular filtration by MDRD <40 mL/min. There were more patients co-treated with rifampin in the group with low Cmin. The only factor independently associated with Cmin >8 was the renal function. Patients with an eGF < 40 mL/min had significantly higher Cmin than those with eGF > 80 mL/min (OR: 4.273) and there was a trend towards a high Cmin in patients with eGF between 40-80 mL/min (OR: 2.109).
High Cmin were frequent, especially in patients with MDRD <40 mL/min. Therapeutic drug monitoring could be useful to avoid toxicity in patients with renal dysfunction.
利奈唑胺的主要关注点是不良反应。高利奈唑胺谷浓度（Cmin）与毒性有关。本研究旨在分析与高 Cmin 相关的因素。
回顾性分析 104 例接受 600mg/12 小时利奈唑胺治疗的患者的主要临床特征。至少给予 3 剂药物后，在治疗的前 8 天内，在下次给药前采集样本。Cmin>8mg/L 时认为 Cmin 较高。进行了单因素和多因素分析。
34.6%的患者 Cmin>8mg/L，他们年龄较大，且经常通过 MDRD 估计肾小球滤过率<40mL/min。低 Cmin 组中有更多患者同时接受利福平治疗。唯一与 Cmin>8 相关的独立因素是肾功能。eGF<40mL/min 的患者 Cmin 明显高于 eGF>80mL/min 的患者（OR：4.273），而 eGF 在 40-80mL/min 之间的患者 Cmin 较高（OR：2.109）。
Cmin 较高，尤其是在 MDRD<40mL/min 的患者中。治疗药物监测可能有助于避免肾功能障碍患者的毒性。
