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采用气道与食管联合入路缓解合并存在的气管支气管和食管疾病

Palliation of Concomitant Tracheobronchial and Esophageal Disease Using a Combined Airway and Esophageal Approach.

作者信息

Nasir Basil S, Tahiri Mehdi, Kazakov Jordan, Thiffault Vicky, Ferraro Pasquale, Liberman Moishe

机构信息

Division of Thoracic Surgery, Vancouver General Hospital, Vancouver, British Columbia.

CHUM Endoscopic Tracheo-bronchial and Oesophageal Center, Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.

出版信息

Ann Thorac Surg. 2016 Aug;102(2):400-6. doi: 10.1016/j.athoracsur.2016.03.021. Epub 2016 May 5.

Abstract

BACKGROUND

Neoplastic involvement of the mediastinum can contribute to both airway and esophageal pathology. That can manifest as combined esophageal and airway stenosis, or tracheobronchoesophageal fistula. Conventional palliative treatment of these problems consists of endoluminal stent insertion. The double stenting approach consists of insertion of a tracheobronchial and an esophageal stent in parallel and allows concomitant symptomatic relief of both the airway and esophageal pathology.

METHODS

The study consists of a retrospective case series of patients who underwent a double stenting procedure for concomitant airway and esophageal disease between August 2009 and September 2014. The type of airway stent chosen was determined based on the pathology and the level of the lesion (simple tubular in the mid trachea or mainstem bronchus, Y-stent for carina).

RESULTS

Thirty-nine patients were treated using the double stenting approach during a combined procedure over 5 years: 15 patients with tracheobronchoesophageal fistula and 24 with stenosis. Immediate relief of symptoms, defined as resuming oral intake and breathing without an external tracheal device, was observed in 25 patients (64%). Thirty-two patients (82%) were discharged from hospital, and 7 patients died in hospital (18%). Of these 7 deaths, 6 patients died of pulmonary complications. Inhospital complications occurred in 11 patients (28%). Of the patients discharged from the hospital, 14 died during a mean follow-up period of 54 days. Mean and median survival were 49 and 24 days, respectively (range, 1 to 448), and median hospital stay was 3 days (range, 1 to 46).

CONCLUSIONS

Treatment of combined airway and esophageal pathology using a double stenting approach is safe, feasible, provides reasonable immediate palliation of symptoms, and is associated with acceptable morbidity. It is a palliative procedure that allows for early hospital discharge of patients who are diagnosed with an incurable malignancy.

摘要

背景

纵隔的肿瘤累及可导致气道和食管病变。这可表现为食管和气道联合狭窄,或气管支气管食管瘘。这些问题的传统姑息治疗包括腔内支架置入。双支架置入方法是并行插入气管支气管支架和食管支架,可同时缓解气道和食管病变的症状。

方法

本研究为回顾性病例系列,纳入2009年8月至2014年9月间因气道和食管疾病并行双支架置入术的患者。根据病变的病理类型和部位选择气道支架类型(气管中段或主支气管为简单管状支架,隆突处为Y形支架)。

结果

5年期间,39例患者在联合手术中采用双支架置入方法治疗:15例气管支气管食管瘘患者和24例狭窄患者。25例患者(64%)症状立即缓解,定义为无需外部气管装置即可恢复经口进食和呼吸。32例患者(82%)出院,7例患者(18%)在医院死亡。这7例死亡患者中,6例死于肺部并发症。11例患者(28%)发生院内并发症。出院患者中,14例在平均54天的随访期内死亡。平均生存时间和中位生存时间分别为49天和24天(范围1至448天),中位住院时间为3天(范围1至46天)。

结论

采用双支架置入方法治疗气道和食管联合病变安全、可行,能合理地立即缓解症状,且发病率可接受。这是一种姑息性手术,可使诊断为不可治愈恶性肿瘤的患者早期出院。

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