Department of Dermatology, University of California, San Francisco, California.
Department of Medicine, Kaiser Permanente Medical Center, Santa Clara, California.
J Am Acad Dermatol. 2016 Jul;75(1):177-185.e17. doi: 10.1016/j.jaad.2016.02.1151. Epub 2016 May 4.
The inflammatory infiltrate seen in biopsy specimens obtained from patients with subcutaneous fat necrosis of the newborn (SCFN) has classically been described as consisting mostly of histiocytes. However, we encountered patients with SCFN whose biopsy specimens revealed mostly neutrophils, prompting infection to be an initial consideration.
We sought to describe cases of SCFN in which neutrophils formed the majority of the infiltrate at our institution and in the literature.
We performed a retrospective analysis of patients with SCFN reported at our institution and a literature review of SCFN.
Thirteen cases of SCFN were identified at our institution. In 2 of 13 cases, neutrophils composed >75% of the inflammatory infiltrate, and both lesions were 1 day old. From the literature review, neutrophils were mentioned as a component of the infiltrate in 10 of 124 cases, but in none were neutrophils described as forming the majority of the infiltrate.
This study is limited by its retrospective nature and small sample size.
Neutrophils can comprise most of the inflammatory cells in patients with SCFN, especially early in the course of the disease. This variant of SCFN can be easily mistaken for infection.
新生儿皮下脂肪坏死（SCFN）患者活检标本中的炎症浸润物经典地描述为主要由组织细胞组成。然而，我们遇到了一些 SCFN 患者，其活检标本中主要为中性粒细胞，这促使我们最初考虑感染。
我们旨在描述在我们机构和文献中中性粒细胞构成浸润物主要成分的 SCFN 病例。
我们对我院报告的 SCFN 患者进行了回顾性分析，并对 SCFN 文献进行了综述。
在我院发现了 13 例 SCFN。在 13 例病例中的 2 例中，中性粒细胞占炎症浸润物的>75%，且这两个病变均为 1 天。从文献综述中，124 例中有 10 例提到中性粒细胞是浸润物的组成部分，但没有任何病例描述为中性粒细胞构成浸润物的主要成分。
本研究受其回顾性性质和小样本量的限制。
中性粒细胞可构成 SCFN 患者炎症细胞的大部分，尤其是在疾病早期。这种 SCFN 变体很容易被误诊为感染。
