Jana Sougata, Sen Kalyan Kumar, Gandhi Arijit
Department of Pharmaceutics, Gupta College of Technological Sciences, Ashram More, G.T. Road, Asansol- 713301, West Bengal, India.
Curr Pharm Des. 2016;22(22):3399-410. doi: 10.2174/1381612822666160510125718.
Now a day's natural polymer based nanoparticulate system have been widely studied as particulate vehicles in the bio-medical and pharmaceutical area. Alginate, a natural biopolymer show good biodegradability, biocompatibility and non toxic, has received attention to utilise as a carrier for preparation of polymeric nanoparticles. Chemically and physically alginate can modified easily and obtained various structure having various properties, and versatile applications. Various properties and structure such as biodegradability, gelling property, mechanical strength and cell affinity can be obtained through combination of alginate with other biopolymers, immobilization of specific molecules such as sugar molecules and peptide through chemical or physical cross-linking.
In this article, we report different method of preparation of alginate nanoparticles, and also focus on recent advances of nanoparticles made of alginate and its modified form in the field of drug delivery applications.
如今，基于天然聚合物的纳米颗粒系统作为生物医学和制药领域的颗粒载体已得到广泛研究。海藻酸盐是一种天然生物聚合物，具有良好的生物降解性、生物相容性且无毒，已受到关注，可作为制备聚合物纳米颗粒的载体。海藻酸盐在化学和物理方面易于改性，可获得具有各种性质和广泛应用的各种结构。通过将海藻酸盐与其他生物聚合物结合，通过化学或物理交联固定特定分子（如糖分子和肽），可获得诸如生物降解性、凝胶化性质、机械强度和细胞亲和力等各种性质和结构。
在本文中，我们报告了海藻酸盐纳米颗粒的不同制备方法，并着重介绍了海藻酸盐及其改性形式制成的纳米颗粒在药物递送应用领域的最新进展。
