与碳、氮和氧配体配位的（芳烃）钌（II）配合物的抗癌活性及作用方式

Anticancer Activity and Modes of Action of (arene) ruthenium(II) Complexes Coordinated to C-, N-, and O-ligands.

作者信息

Biersack Bernhard

机构信息

Organic Chemistry Laboratory, University of Bayreuth, Universitaetsstrasse 30, D-95440 Bayreuth, Germany.

出版信息

Mini Rev Med Chem. 2016;16(10):804-14. doi: 10.2174/138955751610160503004623.

DOI:10.2174/138955751610160503004623

PMID:27161009

Abstract

An overview of anticancer active (arene)ruthenium(II) complexes coordinated to period 2 element-based ligand systems, i.e., carbon-, nitrogen-, and oxygen-coordinated ligands, is provided in this mini-review. A bridge is forged from the large group of anticancer active ruthenium compounds with monodentate and chelating nitrogen ligands via complexes of O,O-chelating ligands to organometallic ruthenium derivatives coordinated to carbon. (Arene)ruthenium(II) complexes with reduced side-effects and enhanced efficacy against cancer are highlighted. Pertinent literature is covered up to 2014.

摘要

本综述简要介绍了与第二周期元素基配体体系（即碳、氮和氧配位配体）配位的抗癌活性（芳烃）钌（II）配合物。从大量具有单齿和螯合氮配体的抗癌活性钌化合物，经由O，O - 螯合配体的配合物，到与碳配位的有机金属钌衍生物，构建起一座桥梁。重点介绍了副作用降低且抗癌疗效增强的（芳烃）钌（II）配合物。涵盖了截至2014年的相关文献。