Zheng Kangdi, Wu Qiong, Ding Yang, Mei Wenjie
Department of School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Mini Rev Med Chem. 2016;16(10):796-803. doi: 10.2174/1389557515666151001142159.
Arene ruthenium(II) complexes have been widely investigated as one of the most promising candidates in chemotherapy because of their low toxicity and high inhibiting activity against the proliferation, invasion, migration, and angiogenesis of various tumors in vitro and in vivo. This review highlights the recent developments in different chemical types of arene Ru(II) complexes, as well as their biological activity and underlying mechanisms. The sustained efforts in this aspect of arene Ru(II) complexes would be essential in developing novel anti-tumor agents in the near future.
由于芳烃钌（II）配合物具有低毒性以及在体外和体内对各种肿瘤的增殖、侵袭、迁移和血管生成具有高抑制活性，它们已作为化疗中最有前景的候选物之一被广泛研究。本文综述了不同化学类型的芳烃钌（II）配合物的最新进展，以及它们的生物活性和潜在机制。芳烃钌（II）配合物在这方面的持续努力对于在不久的将来开发新型抗肿瘤药物至关重要。
