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一名3岁儿童毛细胞型星形细胞瘤的弥漫性脊髓软膜播散

Diffuse Spinal Leptomeningeal Spread of a Pilocytic Astrocytoma in a 3-year-old Child.

作者信息

Alyeldien Ameer, Teuber-Hanselmann Sarah, Cheko Azad, Höll Tanja, Scholz Martin, Petridis Athanasios K

机构信息

Department of Neurosurgery, Sana Kliniken , Duisburg, Germany.

Institute of Neuropathology, University of Duisburg-Essen , Essen, Germany.

出版信息

Clin Pract. 2016 Mar 31;6(1):813. doi: 10.4081/cp.2016.813. eCollection 2016 Mar 25.

Abstract

Pilocytic astrocytomas correspond to low-grade gliomas and therefore metastasize exceedingly rare. However, pilocytic astrocytomas are able to and leptomeningeal dissemination may be seen. What are the treatment options of these cases? We present a case report of a 3-year-old child with a pilocytic astrocytoma of the optic chiasm with leptomeningeal dissemination of the spinal meninges. Partial resection of the cerebral tumor has been performed. Since the leptomeningeal dissemination was seen all over the spinal meninges, the child did not undergo further surgical treatment. A wait and watch strategy were followed. Chemotherapy was initiated, if a 25% tumor growth was seen. Leptomeningeal dissemination of a pilocytic astrocytoma is seen so infrequently that no standard therapy is established. Since these metastases may occur even up to 2 decades after primary tumor resection, long-term follow-up is indicated. In case of spinal metastases, surgical treatment should be performed if feasible. Otherwise observation should be possessed and/or chemotherapy should be initiated.

摘要

毛细胞型星形细胞瘤属于低级别胶质瘤,因此极少发生转移。然而,毛细胞型星形细胞瘤能够发生转移,也可能出现软脑膜播散。这些病例的治疗选择有哪些?我们报告一例3岁儿童,患有视交叉毛细胞型星形细胞瘤并伴有脊髓软脑膜播散。已对脑部肿瘤进行了部分切除。由于在整个脊髓软脑膜均发现有软脑膜播散,该患儿未接受进一步手术治疗,而是采取了观察等待策略。如果肿瘤生长25%,则开始化疗。毛细胞型星形细胞瘤的软脑膜播散极为罕见,尚未确立标准治疗方案。由于这些转移甚至可能在原发性肿瘤切除后长达20年才发生,因此需要进行长期随访。对于脊髓转移,如果可行应进行手术治疗。否则,应进行观察和/或开始化疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb14/4844811/48e15c1c9398/cp-2016-1-813-g001.jpg

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