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一名成年患者的毛细胞型星形细胞瘤发生脊髓播散,该患者最初于18年前被诊断。

Spinal seeding of a pilocytic astrocytoma in an adult, initially diagnosed 18 years previously.

作者信息

Crabtree Kelli L, Arnold Paul M

机构信息

School of Medicine, University of Kansas Medical Center, Kansas City, KS 66160, USA.

出版信息

Pediatr Neurosurg. 2010;46(1):66-70. doi: 10.1159/000315320. Epub 2010 Jun 1.

Abstract

Pilocytic astrocytoma (PA) is a slow-growing, well-circumscribed grade I glioma generally considered benign, with a low recurrence rate and an excellent prognosis following complete surgical resection. PA is the most common central nervous system glioma in the pediatric population and is rare in adults. We report a 26-year-old male with an intradural extramedullary PA at the thoracolumbar junction following subtotal cerebellar PA resection 18 years previously. Fifteen months after spinal PA resection, the patient is doing well, has regained the ability to stand independently, and has no evidence of any new or enlarging lesions. To our knowledge, this is the longest time reported from initial tumor resection of leptomeningeal dissemination to the distal spinal cord. PA patients with subtotal resection may benefit from continued follow-up for up to 20 years after the initial diagnosis and resection.

摘要

毛细胞型星形细胞瘤(PA)是一种生长缓慢、边界清楚的I级胶质瘤,通常被认为是良性的,复发率低,完全手术切除后预后良好。PA是儿童人群中最常见的中枢神经系统胶质瘤,在成人中罕见。我们报告一例26岁男性,18年前小脑PA次全切除术后,在胸腰段交界处发生硬膜内髓外PA。脊髓PA切除术后15个月,患者情况良好,已恢复独立站立能力,且没有任何新的或增大的病变迹象。据我们所知,这是从最初肿瘤切除到软脑膜播散至脊髓远端报道的最长时间。PA次全切除的患者在初始诊断和切除后长达20年的持续随访中可能会受益。

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