Mahdiabadi Fatemeh Musavi, Nikvarz Naemeh
Department of Internal Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
J Res Pharm Pract. 2016 Apr-Jun;5(2):146-8. doi: 10.4103/2279-042X.179585.
Sialadenitis is a rare adverse effect of captopril. We report a case of captopril-induced sialadenitis in a patient with end-stage renal disease (ESRD). A 20-year-old man with ESRD encountered parotid and submandibular swelling after receiving two doses of captopril, administered sublingually. Despite of prescribing dexamethasone, resuming hemodialysis, and discontinuing other drugs that also can cause parotitis, he improved later than what was reported in patients with normal renal function. In conclusion recovery from captopril-induced sialadenitis in patients with ESRD may be more prolonged than that of patients with normal renal function; moreover, early hemodialysis which helps in drug removal may be the most effective treatment.
涎腺炎是卡托普利一种罕见的不良反应。我们报告一例终末期肾病（ESRD）患者发生卡托普利诱发的涎腺炎。一名20岁的ESRD男性患者在舌下含服两剂卡托普利后出现腮腺和颌下腺肿胀。尽管使用了地塞米松、恢复血液透析并停用了其他也可引起腮腺炎的药物，但他的恢复情况比肾功能正常患者的报道要慢。总之，ESRD患者卡托普利诱发的涎腺炎恢复时间可能比肾功能正常患者更长；此外，有助于药物清除的早期血液透析可能是最有效的治疗方法。
