Nathanson S D, Westrick P, Anaya P, Hetzel F W, Lee M
Department of Surgery, Henry Ford Hospital, Detroit, MI 48202.
J Surg Oncol. 1989 May;41(1):33-8. doi: 10.1002/jso.2930410111.
Melanomas growing in the feet of syngeneic C57BL/6 mice were treated with a single dose of X-irradiation. After doses of 0, 3.75, 7.5, 10, 20, or 30 Gy the tumor-bearing limb was amputated at tumor sizes 1, 2, 3, 4, or 5 mm. After doses of 40, 50, 62.5, or 72.5 Gy, progressive tumor growth did not occur, and amputation of tumor-bearing limbs was done when controls were 1, 2, 3, 4, or 5 mm in size. Eighteen days after amputation the mice were killed, and pulmonary metastases were documented at autopsy. None of the mice developed pulmonary metastases after curative irradiation of the primary foot tumor. After subcurative irradiation there was a significant increase (P less than .003) in pulmonary metastases. The size of the primary melanoma is important in the prediction of these metastases. In this model melanomas can be cured by an adequate dose of irradiation, but in those not cured the incidence of lung metastases is increased. The impact of this biologic phenomenon on survival is unclear.
对同基因C57BL/6小鼠足部生长的黑色素瘤进行单次X射线照射治疗。给予0、3.75、7.5、10、20或30 Gy剂量照射后，当肿瘤大小分别为1、2、3、4或5 mm时，将荷瘤肢体截肢。给予40、50、62.5或72.5 Gy剂量照射后，肿瘤未出现进行性生长，当对照组肿瘤大小为1、2、3、4或5 mm时，将荷瘤肢体截肢。截肢18天后处死小鼠，尸检时记录肺转移情况。对足部原发性肿瘤进行根治性照射后，无一例小鼠发生肺转移。亚根治性照射后，肺转移显著增加（P<0.003）。原发性黑色素瘤的大小对预测这些转移很重要。在该模型中，适当剂量的照射可治愈黑色素瘤，但未治愈的黑色素瘤肺转移发生率会增加。这种生物学现象对生存的影响尚不清楚。
