心室舒张的测量。等容舒张时间常数的替代指标。

Measurement of ventricular relaxation. An alternative index of isovolumic relaxation to the time constant.

作者信息

Lee K C

机构信息

Cardiovascular Pharmacology, Wyeth Laboratories, Inc., Philadelphia, Pennsylvania.

出版信息

J Pharmacol Methods. 1989 Apr;21(2):141-53. doi: 10.1016/0160-5402(89)90032-6.

DOI:10.1016/0160-5402(89)90032-6

PMID:2716337

Abstract

The time constant (T) is commonly used for representing the isovolumic fall in left ventricular pressure (LVP) because the isovolumic fall is monoexponential under most circumstances. However, the determination of T is cumbersome due to the requirement of a set of LVP versus time values in fitting a monoexponential function. RT64, which is the time from the minimum value of the time derivative of LVP (-dp/dtmax) to 36% of -dP/dtmax, can be derived beat-by-beat, on-line, and may be a simple alternative to T. Through the use of 240 pairs of values derived from six conscious instrumented dogs treated with different cardiovascular active agents, RT64 and T were found to be significantly correlated (r = 0.835, p less than 0.05) according to the equation RT64 = 0.725T + 10.2. In conclusion, RT64 may provide a simple alternative to T in representing the isovolumic relaxation process of the left ventricle.

摘要

时间常数（T）通常用于表示左心室压力（LVP）的等容下降，因为在大多数情况下，等容下降是单指数的。然而，由于在拟合单指数函数时需要一组LVP与时间的值，T的确定很繁琐。RT64是从左心室压力时间导数的最小值（-dp/dtmax）到-dP/dtmax的36%所需的时间，可以逐搏、在线推导得出，并且可能是T的一个简单替代指标。通过使用从六只接受不同心血管活性药物治疗的清醒插管犬获得的240对数值，根据方程RT64 = 0.725T + 10.2发现RT64与T显著相关（r = 0.835，p < 0.05）。总之，在表示左心室等容舒张过程时，RT64可能是T的一个简单替代指标。