大型学术中心外科患者的慢性阿片类药物使用情况
Chronic Opioid Usage in Surgical Patients in a Large Academic Center.
作者信息
Jiang Xueying, Orton Margaret, Feng Rui, Hossain Erik, Malhotra Neil R, Zager Eric L, Liu Renyu
机构信息
*Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China †Department of Anesthesiology and Critical Care, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA ‡Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA §EPIC Data Report, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA ||Department of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
出版信息
Ann Surg. 2017 Apr;265(4):722-727. doi: 10.1097/SLA.0000000000001780.
OBJECTIVE
The objective of this study is to investigate the prevalence and disparity of chronic opioid usage in surgical patients and the potential risk factors associated with chronic opioid usage.
BACKGROUND
Chronic opioid usage is common in surgical patients; however, the characteristics of opioid usage in surgical patients is unclear. In this study, we hypothesize that the prevalence of chronic opioid usage in surgical patients is high, and that significant disparities may exist among different surgical populations.
METHODS
Data of opioid usage in outpatients among different surgical services were extracted from the electronic medical record database. Patient demographics, clinical characteristics of sex, age, race, body mass index (BMI), specialty visited, duration of opioid use, and opioid type were collected. Chronic opioid users were defined as patients who had been recorded as taking opioids for at least 90 days determined by the first and last visit dates under opioid usage during the investigation.
RESULTS
There were 79,123 patients included in this study. The average prevalence is 9.2%, ranging from 4.4% to 23.8% among various specialties. The prevalence in orthopedics (23.8%), neurosurgery (18.7%), and gastrointestinal surgery (14.4%) ranked in the top three subspecialties. Major factors influencing chronic opioid use include age, Ethnicitiy, Subspecialtiy, and multiple specialty visits. Approximately 75% of chronic users took opioids that belong to the category II Drug Enforcement Administration classification.
CONCLUSIONS
Overall prevalence of chronic opioid usage in surgical patients is high with widespread disparity among different sex, age, ethnicity, BMI, and subspecialty groups. Information obtained from this study provides clues to reduce chronic opioid usage in surgical patients.
目的
本研究旨在调查外科手术患者慢性阿片类药物使用的患病率及差异,以及与慢性阿片类药物使用相关的潜在风险因素。
背景
慢性阿片类药物使用在外科手术患者中很常见;然而,外科手术患者阿片类药物使用的特征尚不清楚。在本研究中,我们假设外科手术患者慢性阿片类药物使用的患病率很高,并且不同外科人群之间可能存在显著差异。
方法
从电子病历数据库中提取不同外科科室门诊患者的阿片类药物使用数据。收集患者的人口统计学信息、性别、年龄、种族、体重指数(BMI)、就诊专科、阿片类药物使用时长及阿片类药物类型等临床特征。慢性阿片类药物使用者定义为在调查期间,根据阿片类药物使用记录的首次和末次就诊日期确定,已记录服用阿片类药物至少90天的患者。
结果
本研究共纳入79123例患者。平均患病率为9.2%,各专科患病率在4.4%至23.8%之间。骨科(23.8%)、神经外科(18.7%)和胃肠外科(14.4%)的患病率位列各亚专科前三。影响慢性阿片类药物使用的主要因素包括年龄、种族、专科及多次专科就诊。约75%的慢性使用者服用的阿片类药物属于美国药品管理局分类中的第二类。
结论
外科手术患者慢性阿片类药物使用的总体患病率较高,不同性别、年龄、种族、BMI及亚专科组之间存在广泛差异。本研究获得的信息为减少外科手术患者慢性阿片类药物使用提供了线索。