Fan Linxiao, Hu Chenxia, Chen Jiajia, Cen Panpan, Wang Jie, Li Lanjuan
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, School of Medicine, First Affiliated Hospital, Zhejiang University, Hangzhou 310003, China.
Int J Mol Sci. 2016 May 5;17(5):650. doi: 10.3390/ijms17050650.
Mesenchymal stem cells (MSCs) are multipotent; non-hematopoietic stem cells. Because of their immunoregulatory abilities; MSCs are widely used for different clinical applications. Compared with that of other immune cells; the investigation of how MSCs specifically regulate B-cells has been superficial and insufficient. In addition; the few experimental studies on this regulation are often contradictory. In this review; we summarize the various interactions between different types or states of MSCs and B-cells; address how different types of MSCs and B-cells affect this interaction and examine how other immune cells influence the regulation of B-cells by MSCs. Finally; we hypothesize why there are conflicting results on the interaction between MSCs and B-cells in the literature.
间充质干细胞（MSCs）是多能的非造血干细胞。由于其免疫调节能力，MSCs被广泛应用于不同的临床领域。与其他免疫细胞相比，关于MSCs如何特异性调节B细胞的研究较为肤浅且不足。此外，关于这种调节的少数实验研究结果往往相互矛盾。在本综述中，我们总结了不同类型或状态的MSCs与B细胞之间的各种相互作用，探讨不同类型的MSCs和B细胞如何影响这种相互作用，并研究其他免疫细胞如何影响MSCs对B细胞的调节。最后，我们推测了文献中关于MSCs与B细胞相互作用结果相互矛盾的原因。
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