Horyniecki Maciej, Konieczna Marta, Torbus Magdalena, Pierzchała Krystyna, Wawrzyńczyk Maciej, Łabuz-Roszak Beata
Katedra i Klinika Neurologii w Zabrzu Śląski Uniwersytet Medyczny, Katowice.
Wiad Lek. 2016;69(1 Pt 2):92-8.
Neurosarcoidosis (NS) manifests itself clinically in approximately 8-13% of patients with sarcoidosis. Granulomas are localized in both the central and peripheral nervous system, mainly within the meninges and cranial nerves. Changes may spread interstitially, occupying different structures of the brain and spinal cord. Diagnosis of NS is made by characteristic clinical symptoms and the exclusion of other diseases, with the presence of specific changes in the magnetic resonance and cerebrospinal fluid, and it is mainly based on histopathological examination. The first choice treatment are corticosteroids. In case of failure or adverse events, methotrexate, azathioprine, cyclosporine, cyclophosphamide, mycophenolate mofetil and infliximab could be used.
神经结节病（NS）在约8% - 13%的结节病患者中出现临床症状。肉芽肿位于中枢和周围神经系统，主要在脑膜和颅神经内。病变可能沿间质扩散，累及脑和脊髓的不同结构。NS的诊断依据特征性临床症状并排除其他疾病，结合磁共振成像和脑脊液的特定改变，主要基于组织病理学检查。首选治疗药物为糖皮质激素。若治疗失败或出现不良事件，可使用甲氨蝶呤、硫唑嘌呤、环孢素、环磷酰胺、霉酚酸酯和英夫利昔单抗。
