阿司匹林的使用与治疗性支气管镜检查后出血并发症的风险
Aspirin use and the risk of bleeding complications after therapeutic bronchoscopy.
作者信息
Harris Kassem, Kebbe Jad, Modi Kush, Alraiyes Abdul Hamid, Kumar Abhishek, Attwood Kristopher, Dhillon Samjot S
机构信息
Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14623, USA
Division of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine University, Buffalo, State University of New York, Buffalo, NY, USA.
出版信息
Ther Adv Respir Dis. 2016 Aug;10(4):318-23. doi: 10.1177/1753465816646049. Epub 2016 May 10.
BACKGROUND
Aspirin use has been shown to be safe for patients undergoing certain diagnostic bronchoscopy procedures such as transbronchial biopsies and endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration. However, there are no studies documenting the safety of aspirin in patients undergoing therapeutic bronchoscopy. The aim of this study is to evaluate whether aspirin increases the risk of bleeding following therapeutic bronchoscopy.
METHODS
This was a retrospective study to determine if there was a higher risk of bleeding in patients on aspirin undergoing therapeutic bronchoscopy compared with those not on aspirin. Patient characteristics were reported by cohort using the mean, median, and standard deviation for continuous variables, and using frequencies and relative frequencies for categorical variables.
RESULTS
Of the 108 patients who had multimodality therapeutic bronchoscopy, 17 (15.7%) were taking aspirin and 91 (84.3%) were not on aspirin. Patients in the aspirin group were older than those in the no aspirin group (median age: 66 versus 60 years, p = 0.007). The treatment modalities were similar in both groups except that more patients in the no aspirin group were treated with argon plasma coagulation (APC) compared to the aspirin group (60.4% versus 29.4%, p = 0.031). The estimated blood loss (EBL) between the aspirin and no aspirin groups was not significantly different (mean: 6.0 versus 6.7 ml; median: 5.0 versus 5.0, p = 0.36). Overall, there was no difference in complications between both groups.
CONCLUSION
Aspirin use was not associated with increased risk of bleeding or procedure-related complications after therapeutic bronchoscopy.
背景
已证明阿司匹林对接受某些诊断性支气管镜检查程序（如经支气管活检和支气管内超声（EBUS）引导下经支气管针吸活检）的患者是安全的。然而，尚无研究记录阿司匹林在接受治疗性支气管镜检查患者中的安全性。本研究的目的是评估阿司匹林是否会增加治疗性支气管镜检查后出血的风险。
方法
这是一项回顾性研究，以确定接受治疗性支气管镜检查的阿司匹林使用者与未使用阿司匹林者相比，出血风险是否更高。采用连续变量的均值、中位数和标准差以及分类变量的频率和相对频率按队列报告患者特征。
结果
在108例接受多模式治疗性支气管镜检查的患者中，17例（15.7%）正在服用阿司匹林，91例（84.3%）未服用阿司匹林。阿司匹林组患者比未服用阿司匹林组患者年龄更大（中位年龄：66岁对60岁，p = 0.007）。两组的治疗方式相似，只是与阿司匹林组相比，未服用阿司匹林组接受氩等离子体凝固（APC）治疗的患者更多（60.4%对29.
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