Fujii Hideki, Nishimoto Naoki, Yamaguchi Seiko, Kurai Osamu, Miyano Masato, Ueda Wataru, Oba Hiroko, Aoki Tetsuya, Kawada Norifumi, Okawa Kiyotaka
Department of Gastroenterology and Hepatology, Osaka City Juso Hospital, Nonaka-kita, Yodogawa, Osaka, 532-0034, Japan.
Department of Radiological Technology, Hokkaido University of Science, Maeda, Teine, Sapporo, Hokkaido, 006-8585, Japan.
BMC Public Health. 2016 May 10;16:379. doi: 10.1186/s12889-016-3053-6.
It is important to screen for alcohol consumption and drinking customs in a standardized manner. The aim of this study was 1) to investigate whether the AUDIT score is useful for predicting hazardous drinking using optimal cutoff scores and 2) to use multivariate analysis to evaluate whether the AUDIT score was more useful than pre-existing laboratory tests for predicting hazardous drinking.
A cross-sectional study using the Alcohol Use Disorders Identification Test (AUDIT) was conducted in 334 outpatients who consulted our internal medicine department. The patients completed self-reported questionnaires and underwent a diagnostic interview, physical examination, and laboratory testing.
Forty (23 %) male patients reported daily alcohol consumption ≥ 40 g, and 16 (10 %) female patients reported consumption ≥ 20 g. The optimal cutoff values of hazardous drinking were calculated using a 10-fold cross validation, resulting in an optimal AUDIT score cutoff of 8.2, with a sensitivity of 95.5 %, specificity of 87.0 %, false positive rate of 13.0 %, false negative rate of 4.5 %, and area under the receiver operating characteristic curve of 0.97. Multivariate analysis revealed that the most popular short version of the AUDIT consisting solely of its three consumption items (AUDIT-C) and patient sex were significantly associated with hazardous drinking. The aspartate transaminase (AST)/alanine transaminase (ALT) ratio and mean corpuscular volume (MCV) were weakly significant.
This study showed that the AUDIT score and particularly the AUDIT-C score were more useful than the AST/ALT ratio and MCV for predicting hazardous drinking.
以标准化方式筛查饮酒情况和饮酒习惯很重要。本研究的目的是：1）使用最佳临界值研究酒精使用障碍识别测试（AUDIT）分数是否有助于预测危险饮酒；2）使用多变量分析评估AUDIT分数在预测危险饮酒方面是否比现有的实验室检查更有用。
对334名到我院内科就诊的门诊患者进行了一项采用酒精使用障碍识别测试（AUDIT）的横断面研究。患者完成了自我报告问卷，并接受了诊断性访谈、体格检查和实验室检测。
40名（23%）男性患者报告每日饮酒量≥40克，16名（10%）女性患者报告饮酒量≥20克。使用10倍交叉验证计算危险饮酒的最佳临界值，得出AUDIT分数的最佳临界值为8.2，灵敏度为95.5%，特异度为87.0%，假阳性率为13.0%，假阴性率为4.5%，受试者工作特征曲线下面积为0.97。多变量分析显示，仅由AUDIT的三个饮酒项目组成的最常用简短版本（AUDIT-C）和患者性别与危险饮酒显著相关。天冬氨酸转氨酶（AST）/丙氨酸转氨酶（ALT）比值和平均红细胞体积（MCV）的相关性较弱。
本研究表明，AUDIT分数尤其是AUDIT-C分数在预测危险饮酒方面比AST/ALT比值和MCV更有用。
