中性粒细胞与淋巴细胞比值预测急性脑出血的转归。
Neutrophil-to-Lymphocyte Ratio Predicts the Outcome of Acute Intracerebral Hemorrhage.
机构信息
From the Neurological Clinic, Department of Experimental and Clinical Medicine, Marche Polytechnic University, Ancona, Italy.
出版信息
Stroke. 2016 Jun;47(6):1654-7. doi: 10.1161/STROKEAHA.116.013627. Epub 2016 May 10.
BACKGROUND AND PURPOSE
Increasing evidence suggests that inflammatory mechanisms are involved in the intracerebral hemorrhage-induced brain injury. We evaluated the prognostic role of the peripheral leukocyte counts and neutrophil-to-lymphocyte ratio (NLR) in patients with intracerebral hemorrhage.
METHODS
Patients with acute spontaneous intracerebral hemorrhage were retrospectively identified. Total white blood cells, absolute neutrophil count, and absolute lymphocyte count were obtained and the NLR computed from the admission blood work. The study end point was the occurrence of death or major disability at 3 months.
RESULTS
One hundred seventy-seven subjects were enrolled. Ninety-four (53.1%) had unfavorable outcome. The absolute neutrophil count, absolute lymphocyte count, and NLR were independently associated with the 3-month status. The NLR resulted the best discriminating variable and the best predictive cut-off value was 4.58.
CONCLUSIONS
In patients with acute intracerebral hemorrhage, higher neutrophils, lower lymphocytes, and higher NLRs predicted worse 3-month outcome.
背景与目的
越来越多的证据表明，炎症机制参与了脑出血引起的脑损伤。我们评估了外周白细胞计数和中性粒细胞与淋巴细胞比值（NLR）在脑出血患者中的预后作用。
方法
回顾性地确定了急性自发性脑出血患者。从入院时的血液检查中获得了总白细胞计数、绝对中性粒细胞计数和绝对淋巴细胞计数，并计算了 NLR。研究终点为 3 个月时的死亡或主要残疾。
结果
共纳入 177 例患者，94 例（53.1%）预后不良。绝对中性粒细胞计数、绝对淋巴细胞计数和 NLR 与 3 个月时的状态独立相关。NLR 是区分能力最好的变量，最佳预测截断值为 4.58。
结论
在急性脑出血患者中，较高的中性粒细胞、较低的淋巴细胞和较高的 NLR 预示着 3 个月时的预后更差。
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