Xu Wenhao, Wang Peng, Wan Jun, He Jialing, Zheng Yuxin, Liu Yuyang, Peng Liyuan, Xiao Yangchun, Feng Yuning, Cheng Xin, Fang Fang, Zhang Yu
Center for Evidence-Based Medicine, Affiliated Hospital of Chengdu University, No. 82, North Section 2, 2nd Ring Road, Jinniu District, Chengdu, 610081, Sichuan, China.
Department of Neurosurgery, Affiliated Hospital of Chengdu University, Chengdu, Sichuan, China.
Sci Rep. 2025 Jul 14;15(1):25355. doi: 10.1038/s41598-025-08520-2.
Deep vein thrombosis (DVT) is a common and serious complication of spontaneous intracerebral hemorrhage (ICH). The timely recognition and treatment of DVT can significantly mitigate several negative consequences. To investigate the association between the neutrophil-to-high-density lipoprotein cholesterol ratio (NHR) and the occurrence of DVT in ICH patients. This multicenter, retrospective cohort study included patients diagnosed with ICH from three hospitals. The primary outcome was the occurrence of DVT. The NHR was calculated using complete blood counts. Receiver operating characteristic (ROC) analysis was performed to determine the optimal NHR threshold for predicting DVT and to compare its predictive performance with that of other biomarkers. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with DVT and to explore clinical complications related to NHR. A total of 5,004 patients were ultimately included in this study, among whom 359 (7.2%) were diagnosed with DVT. The optimal NHR cutoff for predicting DVT was 6.55, based on the Youden Index from the ROC curve, and was used to dichotomize the study population. In multivariable analyses, even after adjustment, a higher NHR was associated with an increased occurrence of DVT (adjusted odds ratio 1.69, 95% confidence interval 1.33-2.16) and its complications. Additionally, ROC analysis showed that NHR had superior predictive ability for DVT compared to single markers. In patients with ICH, a high NHR (≥ 6.55) independently predicts DVT and may serve as a laboratory marker for its occurrence.
深静脉血栓形成（DVT）是自发性脑出血（ICH）常见且严重的并发症。及时识别和治疗DVT可显著减轻多种不良后果。为研究中性粒细胞与高密度脂蛋白胆固醇比值（NHR）与ICH患者发生DVT之间的关联。这项多中心回顾性队列研究纳入了来自三家医院诊断为ICH的患者。主要结局是DVT的发生。使用全血细胞计数计算NHR。进行受试者工作特征（ROC）分析以确定预测DVT的最佳NHR阈值，并将其预测性能与其他生物标志物进行比较。进行单因素和多因素逻辑回归分析以确定与DVT相关的因素，并探索与NHR相关的临床并发症。本研究最终共纳入5004例患者，其中359例（7.2%）被诊断为DVT。根据ROC曲线的约登指数，预测DVT的最佳NHR临界值为6.55，并用于将研究人群二分。在多变量分析中，即使经过调整，较高的NHR仍与DVT及其并发症的发生率增加相关（调整后的优势比为1.69，95%置信区间为1.33 - 2.16）。此外，ROC分析表明，与单一标志物相比，NHR对DVT具有更好的预测能力。在ICH患者中，高NHR（≥6.55）可独立预测DVT，并可作为其发生的实验室标志物。
