Sultan Khushbakht, Zakir Muhammad, Khan Haroon, Khan Ihsaan Ullah, Ayaz Sultan, Khan Iqbal, Khan Jafar, Khan Murad Ali
Department of Chemistry, Kohat University of Science and Technology, Kohat, Pakistan.
Department of Pharmacy, Abdul Wali Khan University Mardan 23200, Pakistan.
Pak J Pharm Sci. 2016 May;29(3):837-42.
The present study was designed to investigate the antihyperglycemic effect of Persea duthieion blood glucose concentration and body weight in alloxan induced diabetic hyperglycemic rabbits. The results illustrated significant antihyperglycemic activity of crude extract with 17.44% and 28.02% amelioration at 25 and 50mg/kg p.o. respectively after 24th day of drug treatment; equally supported by body weight recovery. Upon fractionation, most dominant antihyperglycemic effect was displayed by aqueous fraction with 22.12% and 34.43% effect followed by ethyl acetate fraction with 24.32% and 32.05% effect at 25 and 50mg/kg p.o. respectively after 24th day of drug treatment. The effect on blood glucose was also reflected on body weight of animals. In conclusion, our study documented marked antihyperglycemic activity of extract/fractions of P. duthiei.
本研究旨在探讨滇楠提取物对四氧嘧啶诱导的糖尿病高血糖兔血糖浓度和体重的降血糖作用。结果表明，药物治疗第24天后，粗提物具有显著的降血糖活性，口服25mg/kg和50mg/kg时，血糖改善率分别为17.44%和28.02%；体重恢复也同样证明了这一点。分级分离后，水相部分显示出最显著的降血糖作用，药物治疗第24天后，口服25mg/kg和50mg/kg时，血糖降低率分别为22.12%和34.43%，其次是乙酸乙酯部分，血糖降低率分别为24.32%和32.05%。对血糖的影响也反映在动物体重上。总之，我们的研究记录了滇楠提取物/馏分具有显著的降血糖活性。
